PMID- 23588886
OWN - NLM
STAT- MEDLINE
DCOM- 20130827
LR  - 20221207
IS  - 1432-1211 (Electronic)
IS  - 0093-7711 (Linking)
VI  - 65
IP  - 7
DP  - 2013 Jul
TI  - Association analysis of the HLA-C gene in Japanese alopecia areata.
PG  - 553-7
LID - 10.1007/s00251-013-0703-z [doi]
AB  - Alopecia areata (AA) is an organ-specific and cell-mediated autoimmune disease 
      involving hair loss, but its pathogenesis remains poorly understood. Many 
      autoimmune diseases are genetically associated with alleles of the human 
      leukocyte antigen (HLA) genes within the major histocompatibility complex. 
      Associations between AA and HLA genes were previously observed in some different 
      ethnic groups. However, the results were inconsistent, and a primary 
      susceptibility HLA gene and/or region has not yet been assigned for AA. The aim 
      of this study was to evaluate whether an allele of the HLA-C locus, HLA-C*07:04, 
      which was strongly associated with AA in Chinese Hans, could be replicated in the 
      Japanese population. The HLA-C locus was genotyped by the SSO method using 156 AA 
      patients and 560 healthy controls. As a consequence, among the 17 alleles 
      detected, only two alleles, C*04:01 (OR = 2.25, CI 95 % = 1.35-3.75, 
      P = 1.84E-03) and C*15:02 (OR = 2.52, CI 95 % = 1.37-4.64, P = 2.90E-03), were 
      significantly associated with AA after Bonferroni correction. Further, the 
      stratification analysis suggested that C*04:01, C*07:02, and C*15:02 represented 
      different AA genetic risk factors in each sub-phenotype.
FAU - Haida, Yuko
AU  - Haida Y
AD  - Department of Molecular Life Science, Division of Basic Medical Science and 
      Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, 
      Isehara, Kanagawa 259-1193, Japan.
FAU - Ikeda, Shigaku
AU  - Ikeda S
FAU - Takagi, Atsushi
AU  - Takagi A
FAU - Komiyama, Etsuko
AU  - Komiyama E
FAU - Mabuchi, Tomotaka
AU  - Mabuchi T
FAU - Ozawa, Akira
AU  - Ozawa A
FAU - Kulski, Jerzy K
AU  - Kulski JK
FAU - Inoko, Hidetoshi
AU  - Inoko H
FAU - Oka, Akira
AU  - Oka A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130416
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - Alleles
MH  - Alopecia Areata/ethnology/*genetics
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-C Antigens/*genetics
MH  - Humans
MH  - Japan/epidemiology
MH  - Risk Factors
EDAT- 2013/04/17 06:00
MHDA- 2013/08/28 06:00
CRDT- 2013/04/17 06:00
PHST- 2013/03/25 00:00 [received]
PHST- 2013/04/03 00:00 [accepted]
PHST- 2013/04/17 06:00 [entrez]
PHST- 2013/04/17 06:00 [pubmed]
PHST- 2013/08/28 06:00 [medline]
AID - 10.1007/s00251-013-0703-z [doi]
PST - ppublish
SO  - Immunogenetics. 2013 Jul;65(7):553-7. doi: 10.1007/s00251-013-0703-z. Epub 2013 
      Apr 16.