PMID- 23588893
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130524
LR  - 20211021
IS  - 1523-3847 (Print)
IS  - 1523-3847 (Linking)
VI  - 15
IP  - 3
DP  - 2013 Jun
TI  - Penicillin failure in the treatment of streptococcal pharyngo-tonsillitis.
PG  - 232-5
LID - 10.1007/s11908-013-0338-0 [doi]
AB  - The inadequate penetration of penicillins into the tonsillar tissues and 
      tonsillar surface fluid and microbiologic interactions between Group A 
      beta-hemolytic streptococci (GABHS) and other pharyngo-tonsillar bacterial flora 
      can account for their failure in eradicating GABHS pharyngo-tonsillitis (PT). 
      These interactions include the presence of beta-lactamase producing bacteria 
      (BLPB) that "shield" GABHS from penicillins, the absence of bacteria that 
      interfere with the growth of GABHS, and the coaggregation between GABHS and 
      Moraxella catarrhalis. In the treatment of acute tonsillitis, the use of 
      cephalosporins can overcome these interactions by eradicating aerobic BLPB, while 
      preserving the potentially interfering organisms and eliminating GABHS. In 
      treatment of recurrent and chronic PT, the administration of clindamycin or 
      amoxicillin-clavulanatecan eradicates both aerobic and anaerobic BLPB, as well as 
      GABHS.
FAU - Brook, Itzhak
AU  - Brook I
AD  - Department of Pediatrics and Medicine, Georgetown University School of Medicine, 
      4431 Albemarle St. NW, Washington, DC, 20016, USA, ib6@georgetown.edu.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Curr Infect Dis Rep
JT  - Current infectious disease reports
JID - 100888983
EDAT- 2013/04/17 06:00
MHDA- 2013/04/17 06:01
CRDT- 2013/04/17 06:00
PHST- 2013/04/17 06:00 [entrez]
PHST- 2013/04/17 06:00 [pubmed]
PHST- 2013/04/17 06:01 [medline]
AID - 10.1007/s11908-013-0338-0 [doi]
PST - ppublish
SO  - Curr Infect Dis Rep. 2013 Jun;15(3):232-5. doi: 10.1007/s11908-013-0338-0.