PMID- 23589091
OWN - NLM
STAT- MEDLINE
DCOM- 20131029
LR  - 20140523
IS  - 1549-5485 (Electronic)
IS  - 1072-0502 (Linking)
VI  - 20
IP  - 5
DP  - 2013 Apr 15
TI  - A BDNF sensitive mechanism is involved in the fear memory resulting from the 
      interaction between stress and the retrieval of an established trace.
PG  - 245-55
LID - 10.1101/lm.029306.112 [doi]
AB  - The present study investigates the fear memory resulting from the interaction of 
      a stressful experience and the retrieval of an established fear memory trace. 
      Such a combination enhanced both fear expression and fear retention in adult 
      Wistar rats. Likewise, midazolam intra-basolateral amygdala (BLA) infusion prior 
      to stress attenuated the enhancement of fear memory thus suggesting the 
      involvement of a stress-induced reduction of the GABAergic transmission in BLA in 
      the stress-induced enhancing effect. It has been suggested that, unlike the 
      immediate-early gene Zif268 which is related to the reconsolidation process, the 
      expression of hippocampal brain-derived neurotrophic factor (BDNF) is highly 
      correlated with consolidation. We therefore evaluate the relative contribution of 
      these two neurobiological processes to the fear memory resulting from the 
      above-mentioned interaction. Intra-dorsal hippocampus (DH) infusions of either 
      the antisense Zif268 or the inhibitor of the protein degradation 
      (Clasto-Lactacystin beta-Lactone), suggested to be involved in the 
      retrieval-dependent destabilization process, did not affect the resulting 
      contextual memory. In contrast, the knockdown of hippocampal BDNF mitigated the 
      stress-induced facilitating influence on fear retention. In addition, the 
      retrieval experience elevated BDNF level in DH at 60 min after recall exclusively 
      in stressed animals. These findings suggest the involvement of a hippocampal BDNF 
      sensitive mechanism in the stress-promoting influence on the fear memory 
      following retrieval.
FAU - Giachero, Marcelo
AU  - Giachero M
AD  - IFEC-CONICET, Departamento de Farmacologia, Facultad de Ciencias Quimicas, 
      Universidad Nacional de Cordoba, Haya de Torre y Medina Allende, Ciudad 
      Universitaria, (5000) Cordoba, Argentina.
FAU - Bustos, Silvia G
AU  - Bustos SG
FAU - Calfa, Gaston
AU  - Calfa G
FAU - Molina, Victor A
AU  - Molina VA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130415
PL  - United States
TA  - Learn Mem
JT  - Learning & memory (Cold Spring Harbor, N.Y.)
JID - 9435678
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Early Growth Response Protein 1)
RN  - 0 (Egr1 protein, rat)
RN  - 0 (GABA Modulators)
RN  - 0 (Lactones)
RN  - 0 (Oligodeoxyribonucleotides, Antisense)
RN  - 155975-72-7 (clasto-lactacystin beta-lactone)
RN  - R60L0SM5BC (Midazolam)
SB  - IM
MH  - Amygdala/drug effects/*metabolism
MH  - Animals
MH  - Behavior, Animal/drug effects/physiology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Early Growth Response Protein 1/antagonists & inhibitors
MH  - Fear/drug effects/*physiology
MH  - GABA Modulators/pharmacology
MH  - Hippocampus/drug effects/*metabolism
MH  - Lactones/pharmacology
MH  - Male
MH  - Memory/drug effects/*physiology
MH  - Midazolam/pharmacology
MH  - Oligodeoxyribonucleotides, Antisense/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Stress, Psychological/*metabolism
EDAT- 2013/04/17 06:00
MHDA- 2013/10/30 06:00
CRDT- 2013/04/17 06:00
PHST- 2013/04/17 06:00 [entrez]
PHST- 2013/04/17 06:00 [pubmed]
PHST- 2013/10/30 06:00 [medline]
AID - 20/5/245 [pii]
AID - 10.1101/lm.029306.112 [doi]
PST - epublish
SO  - Learn Mem. 2013 Apr 15;20(5):245-55. doi: 10.1101/lm.029306.112.