PMID- 23590002
OWN - NLM
STAT- MEDLINE
DCOM- 20130821
LR  - 20200929
IS  - 0392-2936 (Print)
IS  - 0392-2936 (Linking)
VI  - 34
IP  - 1
DP  - 2013
TI  - HLA DRB allele polymorphisms and risk of cervical cancer associated with human 
      papillomavirus infection: a population study in China.
PG  - 54-9
AB  - OBJECTIVE: Persistent infection with high-risk human papillomavirus (HPV) is the 
      main cause of cervical cancer. Environmental, behavioral, and ill-defined genetic 
      factors have also been implicated in the pathogenesis of this disease. To 
      determine whether human leukocyte antigen (HLA) DRB alleles are associated with 
      cervical cancer and HPV infections in the Chinese population, HLA genotypes were 
      examined in 69 cervical cancer patients and 201 controls. MATERIALS AND METHODS: 
      Polymorphisms in HLA-DRB genes were genotyped using oligoneucleotide arrays, and 
      the magnitude of associations was determined by logistic regression analysis. 
      RESULTS: HLA-DRB1*13 (OR = 4.01 95% CI, 1.703-9.442) and HLA-DRB1*3(17) (OR = 
      2.661 95% CI, 1.267-5.558) were associated with an increased risk of cervical 
      cancer, and DRB1*09012 (OR = 0.182, 95% CI, 0.079-0.418 and DRB1*1201 (OR = 0.35 
      95% CI, 0.142-0.863 were associated with a decreased risk. The risk associations 
      of HPV infection were increased in women carrying the HLA-DRB1*09012 (OR = 1.924; 
      95% CI, 1.08 -3.427) and DRB3(52)*0101 (OR = 7.527 95% CI, 0.909-62.347) alleles. 
      Among cervical cancer patients, the risk associations differed between HPV 
      positive and negative cases for several alleles; increased risk of cervical 
      cancer was associated with DRB3 (52)*02/03 (OR, 12.794; 95% CI, 5.007-32.691) and 
      DRB1*3(17) (OR = 3.48; 95% CI, 1.261-9.604), and decreased risk was associated 
      with DRB1*09012 and DRB5(51)*01/02. Furthermore, HPV16-containing cervical cancer 
      cases differed from non-HPV16 subjects in their positive association with 
      DRB1*1501 (OR = 4.173; 95% CI, 1.065-16.356) and DRB5(51)*0101/0201, and their 
      negative association with DRB4(53)*0101 (OR = 0.329; 95% CI,0.122-0.888). 
      CONCLUSIONS: The present results provide further evidence that certain HLA class 
      II allele polymorphisms are involved in the genetic susceptibility to cervical 
      cancer and HPV infection in the Chinese population from an area with a high 
      incidence of this neoplasia.
FAU - Zhao, M
AU  - Zhao M
AD  - Institute of Virology, School of Medicine,Wuhan University, Wuhan, Hubei, China.
FAU - Qiu, L
AU  - Qiu L
FAU - Tao, N
AU  - Tao N
FAU - Zhang, L
AU  - Zhang L
FAU - Wu, X
AU  - Wu X
FAU - She, Q
AU  - She Q
FAU - Zeng, F
AU  - Zeng F
FAU - Wang, Y
AU  - Wang Y
FAU - Wei, S
AU  - Wei S
FAU - Wu, X
AU  - Wu X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Singapore
TA  - Eur J Gynaecol Oncol
JT  - European journal of gynaecological oncology
JID - 8100357
RN  - 0 (HLA-DR beta-Chains)
SB  - IM
MH  - Alleles
MH  - China
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-DR beta-Chains/*genetics
MH  - Humans
MH  - Logistic Models
MH  - Papillomavirus Infections/*complications
MH  - *Polymorphism, Genetic
MH  - Risk
MH  - Uterine Cervical Neoplasms/*etiology/genetics
EDAT- 2013/04/18 06:00
MHDA- 2013/08/22 06:00
CRDT- 2013/04/18 06:00
PHST- 2013/04/18 06:00 [entrez]
PHST- 2013/04/18 06:00 [pubmed]
PHST- 2013/08/22 06:00 [medline]
PST - ppublish
SO  - Eur J Gynaecol Oncol. 2013;34(1):54-9.