PMID- 23591055
OWN - NLM
STAT- MEDLINE
DCOM- 20141114
LR  - 20240515
IS  - 1872-9738 (Electronic)
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 38
DP  - 2013 Jul-Aug
TI  - Maternal serum persistent organic pollutants in the Finnish Prenatal Study of 
      Autism: A pilot study.
PG  - 1-5
LID - S0892-0362(13)00117-7 [pii]
LID - 10.1016/j.ntt.2013.04.001 [doi]
AB  - Recent research emphasizes the contribution of environmental as well as genetic 
      factors to the etiology of autism but studies testing associations between 
      chemical exposures and autism have been limited. Prenatal exposure to persistent 
      organic pollutants (POPs) has previously been associated with decrements in 
      cognitive and developmental performance. We conducted a pilot study in the 
      Finnish Prenatal Study of Autism (FiPS-A). Seventy-five cases with autism and 75 
      controls matched on sex, birth year, urbanization and maternal age were sampled 
      from first-born children in the Finnish Maternity Cohort, which includes over 
      1million births. The study sample included births occurring from 1991 to 2000. 
      Subjects were followed up for autism through 2007. DDT, DDE, PCB-118, PCB-138, 
      PCB-153, PCB-156, PCB-170, PCB-180, hexachlorobenzene, and BDE-47 were measured 
      in archived maternal serum samples taken during pregnancy using gas 
      chromatography-high resolution mass spectrometry. Correlations between pollutant 
      measures were assessed and mechanistically-related weighting schemes for 
      summarizing PCB levels were compared. Case and control differences were assessed 
      using graphical and statistical methods. All analytes, with the exception of DDT 
      and BDE-47, were detected above the limit of quantification in all samples. The 
      correlation between levels of individual PCB congeners and weighted summary 
      measures was high (0.71-1.00). Paired t-tests revealed no significant differences 
      between cases and controls for log-transformed mean values of any analyte; 
      however, in an adjusted model the odds ratios for autism were 1.91 (p=0.29) and 
      1.79 (p=0.36) respectively, for subjects with total PCBs and DDE above the 90th 
      percentile of control values. Levels of prenatal PCB exposure in FIPS-A were 
      similar to the levels which previously correlated with poorer neurodevelopmental 
      measures in other populations. Further study in a larger sample will be required 
      to fully determine whether exposure to high POP levels is associated with autism 
      diagnosis in the population.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Cheslack-Postava, Keely
AU  - Cheslack-Postava K
AD  - Department of Epidemiology, Columbia University Mailman School of Public Health, 
      New York, NY, United States. kc2497@columbia.edu
FAU - Rantakokko, Panu V
AU  - Rantakokko PV
FAU - Hinkka-Yli-Salomaki, Susanna
AU  - Hinkka-Yli-Salomaki S
FAU - Surcel, Helja-Marja
AU  - Surcel HM
FAU - McKeague, Ian W
AU  - McKeague IW
FAU - Kiviranta, Hannu A
AU  - Kiviranta HA
FAU - Sourander, Andre
AU  - Sourander A
FAU - Brown, Alan S
AU  - Brown AS
LA  - eng
GR  - K02 MH065422/MH/NIMH NIH HHS/United States
GR  - R01 ES019004/ES/NIEHS NIH HHS/United States
GR  - T32 MH013043/MH/NIMH NIH HHS/United States
GR  - 5K02-MH65422/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130413
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0N97R5X10X (2,2',4,4'-tetrabromodiphenyl ether)
SB  - IM
MH  - Adult
MH  - Autistic Disorder/*chemically induced
MH  - Case-Control Studies
MH  - Environmental Pollutants/blood/*toxicity
MH  - Female
MH  - Halogenated Diphenyl Ethers/blood
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*blood
MH  - Male
MH  - Mothers
MH  - Pilot Projects
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/chemically induced/*psychology
PMC - PMC3713110
MID - NIHMS469561
OTO - NOTNLM
OT  - Autism
OT  - DDE
OT  - PCBs
OT  - Persistent organic pollutants
OT  - Prenatal
EDAT- 2013/04/18 06:00
MHDA- 2014/11/15 06:00
PMCR- 2014/07/01
CRDT- 2013/04/18 06:00
PHST- 2012/12/21 00:00 [received]
PHST- 2013/03/14 00:00 [revised]
PHST- 2013/04/02 00:00 [accepted]
PHST- 2013/04/18 06:00 [entrez]
PHST- 2013/04/18 06:00 [pubmed]
PHST- 2014/11/15 06:00 [medline]
PHST- 2014/07/01 00:00 [pmc-release]
AID - S0892-0362(13)00117-7 [pii]
AID - 10.1016/j.ntt.2013.04.001 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2013 Jul-Aug;38:1-5. doi: 10.1016/j.ntt.2013.04.001. Epub 
      2013 Apr 13.