PMID- 23591056
OWN - NLM
STAT- MEDLINE
DCOM- 20140220
LR  - 20130520
IS  - 1532-2661 (Electronic)
IS  - 0034-5288 (Linking)
VI  - 95
IP  - 1
DP  - 2013 Aug
TI  - Non-structural protein 2 of the porcine reproductive and respiratory syndrome 
      (PRRS) virus: a crucial protein in viral pathogenesis, immunity and diagnosis.
PG  - 1-7
LID - S0034-5288(13)00092-1 [pii]
LID - 10.1016/j.rvsc.2013.03.015 [doi]
AB  - Porcine reproductive and respiratory syndrome (PRRS) is a swine disease of 
      significant economic importance that causes reproductive and respiratory problems 
      in pigs. The replicase non-structural protein 2 (Nsp2) of the porcine 
      reproductive and respiratory syndrome virus (PRRSV) is recognized as the most 
      variable region within the PRRSV genome. This review discusses the molecular 
      characteristics and biological and immunological functions of the PRRSV Nsp2 and 
      its involvement in the virus's pathogenesis. The role of Nsp2 in cell and tissue 
      tropism, replication and growth, and variation and pathogenicity of PRRSV and the 
      differences in virulence among different strains are described in the present 
      review. Nsp2 is an ideal marker for monitoring genetic variation and for 
      developing differential diagnostic tests.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Wang, Feng-Xue
AU  - Wang FX
AD  - State Key Laboratory for Molecular Biology of Special Economic Animals, Institute 
      of Special Economic Animal and Plant Sciences, Chinese Academy of Agricultural 
      Sciences, No. 4899 Juye Street, Changchun, Jilin 130112, PR China.
FAU - Song, Ni
AU  - Song N
FAU - Chen, Li-Zhi
AU  - Chen LZ
FAU - Cheng, Shi-Peng
AU  - Cheng SP
FAU - Wu, Hua
AU  - Wu H
FAU - Wen, Yong-Jun
AU  - Wen YJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130413
PL  - England
TA  - Res Vet Sci
JT  - Research in veterinary science
JID - 0401300
RN  - 0 (Viral Nonstructural Proteins)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Female
MH  - Genetic Variation
MH  - Genotype
MH  - Porcine Reproductive and Respiratory Syndrome/genetics/*immunology/virology
MH  - Porcine respiratory and reproductive syndrome 
      virus/*immunology/metabolism/pathogenicity
MH  - Swine
MH  - Viral Nonstructural Proteins/genetics/*immunology
MH  - Viral Vaccines/genetics/immunology
MH  - Virulence/genetics/immunology
MH  - Virus Replication/genetics/immunology
EDAT- 2013/04/18 06:00
MHDA- 2014/02/22 06:00
CRDT- 2013/04/18 06:00
PHST- 2012/08/30 00:00 [received]
PHST- 2013/03/04 00:00 [revised]
PHST- 2013/03/17 00:00 [accepted]
PHST- 2013/04/18 06:00 [entrez]
PHST- 2013/04/18 06:00 [pubmed]
PHST- 2014/02/22 06:00 [medline]
AID - S0034-5288(13)00092-1 [pii]
AID - 10.1016/j.rvsc.2013.03.015 [doi]
PST - ppublish
SO  - Res Vet Sci. 2013 Aug;95(1):1-7. doi: 10.1016/j.rvsc.2013.03.015. Epub 2013 Apr 
      13.