PMID- 23592659
OWN - NLM
STAT- MEDLINE
DCOM- 20131223
LR  - 20130417
IS  - 1930-739X (Electronic)
IS  - 1930-7381 (Linking)
VI  - 21
IP  - 3
DP  - 2013 Mar
TI  - Nicotinamide nucleotide transhydrogenase mRNA expression is related to human 
      obesity.
PG  - 529-34
LID - 10.1002/oby.20095 [doi]
AB  - OBJECTIVE: A spontaneous deletion in the nicotinamide nucleotide transhydrogenase 
      (Nnt) gene eliminating exons 7-11 in C57BL/6J (B6J) mice is associated with 
      reduced glucose-stimulated insulin secretion in vitro, impaired glucose 
      tolerance, higher epigonadal fat mass, and altered susceptibility to diet induced 
      obesity of male B6J mice was proposed. A potential implication for NNT in human 
      adipose tissue distribution has not been investigated so far. DESIGN AND METHODS: 
      Therefore, NNT mRNA expression in paired human samples of visceral (vis) and 
      subcutaneous (sc) adipose tissue from 221 subjects with a wide range of body mass 
      index (BMI), insulin sensitivity, and glucose tolerance was analyzed. RESULTS: 
      NNT mRNA expression is significantly higher in visceral fat of obese patients and 
      correlates with body weight, BMI, % body fat, visceral and sc fat area, waist and 
      hip circumference, and fasting plasma insulin (FPI). Multivariate linear 
      regression analysis revealed visceral NNT expression as age and gender 
      independent predictor of BMI, waist circumference, visceral fat area, and % body 
      fat, but not FPI and 2 h OGTT glucose. CONCLUSION: In conclusion, a functional 
      relevance of NNT in the development of human obesity and visceral fat 
      distribution was suggested here.
CI  - Copyright (c) 2013 The Obesity Society.
FAU - Heiker, John T
AU  - Heiker JT
AD  - Department of Medicine, Endocrinology and Diabetes, Universitat Leipzig, Leipzig, 
      Germany.
FAU - Kern, Matthias
AU  - Kern M
FAU - Kosacka, Joanna
AU  - Kosacka J
FAU - Flehmig, Gesine
AU  - Flehmig G
FAU - Stumvoll, Michael
AU  - Stumvoll M
FAU - Shang, Edward
AU  - Shang E
FAU - Lohmann, Tobias
AU  - Lohmann T
FAU - Dressler, Miriam
AU  - Dressler M
FAU - Kovacs, Peter
AU  - Kovacs P
FAU - Bluher, Matthias
AU  - Bluher M
FAU - Kloting, Nora
AU  - Kloting N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Obesity (Silver Spring)
JT  - Obesity (Silver Spring, Md.)
JID - 101264860
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Mitochondrial Proteins)
RN  - 0 (RNA, Messenger)
RN  - EC 1.6.1.2 (NADP Transhydrogenase, AB-Specific)
RN  - EC 1.6.1.2 (NNT protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Glucose/analysis
MH  - Body Composition
MH  - Body Mass Index
MH  - Body Weight
MH  - Diet
MH  - Fasting
MH  - Female
MH  - Gene Expression Regulation
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Intra-Abdominal Fat/*metabolism
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Mitochondrial Proteins/genetics/metabolism
MH  - Multivariate Analysis
MH  - NADP Transhydrogenase, AB-Specific/genetics/*metabolism
MH  - Obesity/*genetics/physiopathology
MH  - RNA, Messenger/genetics/*metabolism
MH  - Subcutaneous Fat/metabolism
MH  - Young Adult
EDAT- 2013/04/18 06:00
MHDA- 2013/12/24 06:00
CRDT- 2013/04/18 06:00
PHST- 2012/04/24 00:00 [received]
PHST- 2012/08/20 00:00 [accepted]
PHST- 2013/04/18 06:00 [entrez]
PHST- 2013/04/18 06:00 [pubmed]
PHST- 2013/12/24 06:00 [medline]
AID - 10.1002/oby.20095 [doi]
PST - ppublish
SO  - Obesity (Silver Spring). 2013 Mar;21(3):529-34. doi: 10.1002/oby.20095.