PMID- 23592680
OWN - NLM
STAT- MEDLINE
DCOM- 20131223
LR  - 20130417
IS  - 1930-739X (Electronic)
IS  - 1930-7381 (Linking)
VI  - 21
IP  - 3
DP  - 2013 Mar
TI  - Epicardial adipose tissue assessed by cardiac magnetic resonance imaging in 
      patients with heart failure due to dilated cardiomyopathy.
PG  - E253-61
LID - 10.1002/oby.20149 [doi]
AB  - OBJECTIVE: We sought to investigate the association of the EAT with CMR 
      parameters of ventricular remodelling and left ventricular (LV) dysfunction in 
      patients with non-ischemic dilated cardiomyopathy (DCM). DESIGN AND METHODS: One 
      hundred and fifty subjects (112 consecutive patients with DCM and 48 healthy 
      controls) underwent CMR examination. Function, volumes, dimensions, the LV 
      remodelling index (LVRI), the presence of late gadolinium enhancement (LGE) and 
      the amount of EAT were assessed. RESULTS: Compared to healthy controls, patients 
      with DCM revealed a significantly reduced indexed EAT mass (31.7 +/- 5.6 g/m(2) vs 
      24.0 +/- 7.5 g/m(2) , p<0.0001). There was no difference in the EAT mass between 
      DCM patients with moderate and severe LV dysfunction (23.5 +/- 9.8 g/m(2) vs 24.2 +/- 
      6.6 g/m(2) , P = 0.7). Linear regression analysis in DCM patients showed that 
      with increasing LV end-diastolic mass index (LV-EDMI) (r = 0.417, P < 0.0001), 
      increasing LV end-diastolic volume index (r = 0.251, P = 0.01) and increasing LV 
      end-diastolic diameter (r = 0.220, P = 0.02), there was also a significantly 
      increased amount of EAT mass. However, there was no correlation between the EAT 
      and the LV ejection fraction (r = 0.0085, P = 0.37), right ventricular ejection 
      fraction (r = 0.049, P = 0.6), LVRI (r = 0.116, P = 0.2) and the extent of LGE % 
      (r = 0.189, P = 0.1). Among the healthy controls, the amount of EAT only 
      correlated with increasing age (r = 0.461, P = 0.001), BMI (r = 0.426, P = 0.003) 
      and LV-EDMI (r = 0.346, P = 0.02). CONCLUSION: In patients with DCM the amount of 
      EAT is decreased compared to healthy controls irrespective of LV function 
      impairment. However, an increase in LV mass and volumes is associated with a 
      significantly increase in EAT in patients with DCM.
CI  - Copyright (c) 2012 The Obesity Society.
FAU - Doesch, Christina
AU  - Doesch C
AD  - 1st Department of Medicine, University Medical Centre Mannheim, Medical Faculty 
      Mannheim, University of Heidelberg, Germany. Christina.Doesch@umm.de
FAU - Streitner, Florian
AU  - Streitner F
FAU - Bellm, Steven
AU  - Bellm S
FAU - Suselbeck, Tim
AU  - Suselbeck T
FAU - Haghi, Dariusch
AU  - Haghi D
FAU - Heggemann, Felix
AU  - Heggemann F
FAU - Schoenberg, Stefan O
AU  - Schoenberg SO
FAU - Michaely, Henrik
AU  - Michaely H
FAU - Borggrefe, Martin
AU  - Borggrefe M
FAU - Papavassiliu, Theano
AU  - Papavassiliu T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Obesity (Silver Spring)
JT  - Obesity (Silver Spring, Md.)
JID - 101264860
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adipose Tissue/*chemistry/physiopathology
MH  - Aged
MH  - Cardiomyopathy, Dilated/*physiopathology
MH  - Case-Control Studies
MH  - Diastole/physiology
MH  - Female
MH  - Gadolinium
MH  - Heart/*physiopathology
MH  - Heart Failure/*diagnosis/physiopathology
MH  - Humans
MH  - *Image Processing, Computer-Assisted
MH  - Linear Models
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/diagnosis/physiopathology
MH  - Ventricular Dysfunction, Left/physiopathology
MH  - Ventricular Remodeling/physiology
EDAT- 2013/04/18 06:00
MHDA- 2013/12/24 06:00
CRDT- 2013/04/18 06:00
PHST- 2011/10/31 00:00 [received]
PHST- 2012/08/30 00:00 [revised]
PHST- 2012/10/10 00:00 [accepted]
PHST- 2013/04/18 06:00 [entrez]
PHST- 2013/04/18 06:00 [pubmed]
PHST- 2013/12/24 06:00 [medline]
AID - 10.1002/oby.20149 [doi]
PST - ppublish
SO  - Obesity (Silver Spring). 2013 Mar;21(3):E253-61. doi: 10.1002/oby.20149.