PMID- 23593326
OWN - NLM
STAT- MEDLINE
DCOM- 20131105
LR  - 20211203
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 4
DP  - 2013
TI  - Eight functional polymorphisms in the estrogen receptor 1 gene and endometrial 
      cancer risk: a meta-analysis.
PG  - e60851
LID - 10.1371/journal.pone.0060851 [doi]
LID - e60851
AB  - BACKGROUND AND OBJECTIVE: Emerging evidence indicates that common functional 
      polymorphisms in the estrogen receptor 1 (ESR1) gene may have an impact on an 
      individual's susceptibility to endometrial cancer, but individually published 
      results are inconclusive. The aim of this meta-analysis is to derive a more 
      precise estimation of the associations between eight polymorphisms in the ESR1 
      gene and endometrial cancer risk. METHODS: A literature search of PubMed, Embase, 
      Web of Science and China Biology Medicine (CBM) databases was conducted on 
      publications published before November 1(st), 2012. Crude odds ratios (ORs) with 
      95% confidence intervals (CIs) were calculated. Statistical analyses were 
      performed using the STATA 12.0 software. RESULTS: Thirteen case-control studies 
      were included with a total of 7,649 endometrial cancer cases and 16,855 healthy 
      controls. When all the eligible studies were pooled into the meta-analysis, the 
      results indicated that PvuII (C>T) polymorphism was associated with an increased 
      risk of endometrial cancer, especially among Caucasian populations. There were 
      also significant associations between rs3020314 (C>T) polymorphism and an 
      increased risk of endometrial cancer. Furthermore, rs2234670 (S/L) polymorphism 
      may decrease the risk of endometrial cancer. However, no statistically 
      significant associations were found in XbaI (A>G), Codon 325 (C>G), Codon 243 
      (C>T), VNTR (S/L) and rs2046210 (G>A) polymorphisms. CONCLUSION: The current 
      meta-analysis suggests that PvuII (C>T) and rs3020314 (C>T) polymorphisms may be 
      risk factors for endometrial cancer, especially among Caucasian populations.
FAU - Zhou, Xin
AU  - Zhou X
AD  - Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical 
      University, Liaoning, Shenyang, China.
FAU - Gu, Yang
AU  - Gu Y
FAU - Wang, Ding-Ning
AU  - Wang DN
FAU - Ni, Sha
AU  - Ni S
FAU - Yan, Jun
AU  - Yan J
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20130408
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Estrogen Receptor alpha)
SB  - IM
MH  - Endometrial Neoplasms/ethnology/*genetics
MH  - Estrogen Receptor alpha/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Humans
MH  - *Polymorphism, Single Nucleotide
MH  - Racial Groups/genetics
PMC - PMC3620469
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/04/18 06:00
MHDA- 2013/11/06 06:00
PMCR- 2013/04/08
CRDT- 2013/04/18 06:00
PHST- 2012/12/21 00:00 [received]
PHST- 2013/03/03 00:00 [accepted]
PHST- 2013/04/18 06:00 [entrez]
PHST- 2013/04/18 06:00 [pubmed]
PHST- 2013/11/06 06:00 [medline]
PHST- 2013/04/08 00:00 [pmc-release]
AID - PONE-D-12-40325 [pii]
AID - 10.1371/journal.pone.0060851 [doi]
PST - epublish
SO  - PLoS One. 2013 Apr 8;8(4):e60851. doi: 10.1371/journal.pone.0060851. Print 2013.