PMID- 23593882
OWN - NLM
STAT- MEDLINE
DCOM- 20140728
LR  - 20190923
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 30
IP  - 12
DP  - 2012 Dec
TI  - [Multi-residue determination of five antiviral drugs in chicken tissues by liquid 
      chromatography-electrospray ionization tandem mass spectrometry].
PG  - 1253-9
AB  - A method of liquid chromatography-electrospray ionization tandem mass 
      spectrometry (LC-ESI-MS/MS) for the simultaneous determination of five antiviral 
      drug residues, amantadine, rimantadine, memantine, moroxydine and imiquimod in 
      chicken tissues was developed. The compounds were extracted from the samples with 
      trichloroacetic acid solution and acetonitrile, and then cleaned-up by strong 
      cation exchange (SCX) solid phase extraction cartridges. The analytes were 
      separated on a Xamide column (100 mm x 2.1 mm, 5 microm) and determined 
      qualitatively and quantitatively with tandem mass spectrometry using positive 
      polarity mode under multi-reaction monitoring (MRM) scan type. The limits of 
      detection and the limits of quantification were 0.06 - 0.30 microg/kg and 0.2 - 
      1.0 microg/kg, respectively. The average recoveries of the five drugs were 72.3% 
      - 94.2% in chicken muscle and 70.8% - 92.7% in chicken livers. The relative 
      standard deviations (RSDs) in chicken muscle and livers were 3.5% -11.3% and 5.3% 
      -12.6%, respectively. The method is selective without interference and suitable 
      for the determination and confirmation of the five antiviral drugs in chicken 
      muscle and livers.
FAU - Liu, Zhengcai
AU  - Liu Z
AD  - Fujian Entry-Exit Inspection & Quarantine Bureau, Fuzhou 350001, China. 
      zhengcailiu@yahoo.com.cn
FAU - Yang, Fang
AU  - Yang F
FAU - Yu, Kongjie
AU  - Yu K
FAU - Lin, Yonghui
AU  - Lin Y
FAU - Liu, Suzhen
AU  - Liu S
FAU - Zhang, Qiong
AU  - Zhang Q
FAU - Su, Zhijiao
AU  - Su Z
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Antiviral Agents)
SB  - IM
MH  - Animals
MH  - Antiviral Agents/*analysis
MH  - Chickens/*metabolism
MH  - *Chromatography, Liquid
MH  - Drug Residues/*analysis
MH  - Liver/metabolism
MH  - Muscle, Skeletal/metabolism
MH  - *Spectrometry, Mass, Electrospray Ionization
MH  - Tandem Mass Spectrometry
EDAT- 2013/04/19 06:00
MHDA- 2014/07/30 06:00
CRDT- 2013/04/19 06:00
PHST- 2013/04/19 06:00 [entrez]
PHST- 2013/04/19 06:00 [pubmed]
PHST- 2014/07/30 06:00 [medline]
AID - 10.3724/sp.j.1123.2012.07038 [doi]
PST - ppublish
SO  - Se Pu. 2012 Dec;30(12):1253-9. doi: 10.3724/sp.j.1123.2012.07038.