PMID- 23594170
OWN - NLM
STAT- MEDLINE
DCOM- 20140211
LR  - 20220317
IS  - 1460-2202 (Electronic)
IS  - 0271-3683 (Linking)
VI  - 38
IP  - 8
DP  - 2013 Aug
TI  - Point-wise relationships between visual field sensitivity and macular thickness 
      determined by spectral-domain optical coherence tomography.
PG  - 894-901
LID - 10.3109/02713683.2013.787433 [doi]
AB  - PURPOSE: To evaluate the point-wise relationships between visual field 
      sensitivity (VFS), as measured by standard automated perimetry (SAP), and macular 
      thickness, as determined by spectral-domain optical coherence tomography 
      (SD-OCT), in patients with glaucoma. MATERIALS AND METHODS: One hundred and six 
      glaucoma subjects (one eye per subject) recruited from an academic institution 
      underwent SAP tests (Humphrey field analyzer, central 24-2 of Swedish Interactive 
      Thresholding Algorithm standard) and SD-OCT volume scans (SPECTRALIS, posterior 
      pole asymmetry analysis). The retinal sensitivities of 16 central test points 
      from the SAP results were recorded. Macular thickness values from 4 square cells 
      in an 8 x 8 posterior pole retinal thickness map were averaged for a mean retinal 
      thickness (MRT) value, which corresponded to the 16 central test points in the 
      SAP. In each 16-point area, linear regression analyses of the VFS and the MRT 
      value were performed. RESULTS: The VFS of each 16 central test point showed a 
      significant relationship with the corresponding MRT values (R(2)= 0.133-0.383, 
      all p < 0.001). Central and nasal test points corresponding to an arcuate region 
      revealed a relatively strong correlation in both the superior and inferior 
      hemispheres (R(2)= 0.311-0.383 and 0.288-0.345, respectively), but the superior 
      and inferior-temporal points revealed a relatively weaker correlation 
      (R(2)= 0.149 and 0.133, respectively). CONCLUSIONS: The VFS showed a significant 
      reciprocal relationship with corresponding macular thickness at each test point. 
      However, the level of the relationship varied among different macular sectors, 
      showing the strongest relationship in the arcuate region.
FAU - Kim, Joon Mo
AU  - Kim JM
AD  - Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University 
      School of Medicine, Seoul, Korea.
FAU - Sung, Kyung Rim
AU  - Sung KR
FAU - Yoo, Young Cheol
AU  - Yoo YC
FAU - Kim, Chan Yun
AU  - Kim CY
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130417
PL  - England
TA  - Curr Eye Res
JT  - Current eye research
JID - 8104312
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Glaucoma/*pathology
MH  - Humans
MH  - Macula Lutea/*pathology
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
MH  - Retinal Ganglion Cells/pathology
MH  - Sensitivity and Specificity
MH  - *Severity of Illness Index
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Field Tests/*methods
MH  - Visual Fields/*physiology
MH  - Young Adult
EDAT- 2013/04/19 06:00
MHDA- 2014/02/12 06:00
CRDT- 2013/04/19 06:00
PHST- 2013/04/19 06:00 [entrez]
PHST- 2013/04/19 06:00 [pubmed]
PHST- 2014/02/12 06:00 [medline]
AID - 10.3109/02713683.2013.787433 [doi]
PST - ppublish
SO  - Curr Eye Res. 2013 Aug;38(8):894-901. doi: 10.3109/02713683.2013.787433. Epub 
      2013 Apr 17.