PMID- 23594347
OWN - NLM
STAT- MEDLINE
DCOM- 20140103
LR  - 20130507
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 81
IP  - 6
DP  - 2013 Jun
TI  - HLA associations with tubulointerstitial nephritis with or without uveitis in 
      Finnish pediatric population: a nation-wide study.
PG  - 435-41
LID - 10.1111/tan.12116 [doi]
AB  - The human leukocyte antigen (HLA) genotype has been shown to associate with 
      tubulointerstitial nephritis (TIN) and tubulointerstitial nephritis with uveitis 
      syndrome (TINU). The association of HLA genes with TIN was examined in this 
      nation-wide study. HLA genotyping was performed in 31 pediatric patients with 
      biopsy-proven TIN. All patients were examined by an ophthalmologist to diagnose 
      possible uveitis. Class II HLA genotypes of TIN patients were compared with the 
      Finnish reference population. We found a significant association between the HLA 
      alleles DQA1*04:01 [risk ratio (RR) 5.0, 95% confidence interval (CI) 2.0-11.2], 
      DQB1*04:02 (RR 2.7, 95% CI 1.4-5.3), and DRB1*08 (RR 3.8, 95% CI 1.5-8.4) and 
      TIN. Uveitis was found in 20/31 (64.5%) patients. HLA genotyping of the TINU 
      patients showed additional risk HLA alleles: DQA1*01:04 (RR 6.1, 95% CI 
      1.5-17.8), and DRB1*14 (RR 8.2, 95% CI 2.2-22.1). The alleles DQA1*01:04 (RR 8.8, 
      95% CI 2.2-26.5), DQA1*04:01 (RR 3.2, 95% CI 1.2-7.3), and DRB1*14 (RR 12.0, 95% 
      CI 3.2-33.0) were more frequent in patients with TIN and chronic uveitis than in 
      reference population. The HLA class II haplotype DQA1*04:01/DQB1:04:02/DRB1*08 
      was the most common combination in our study population (58.1%). None of the 
      patients had haplotype DQA1*04:01/DQB1*06:02/DRB1*15, which is common in Finland. 
      HLA genotype did not predict the renal outcome. We found a strong association 
      between certain HLA genotypes both in TIN and TINU patients. The 
      TIN/TINU-associated HLA alleles appear to vary depending on study population.
CI  - (c) 2013 John Wiley & Sons Ltd.
FAU - Perasaari, J
AU  - Perasaari J
AD  - Clinical Laboratory, Finnish Red Cross Blood Service, Helsinki, Finland.
FAU - Saarela, V
AU  - Saarela V
FAU - Nikkila, J
AU  - Nikkila J
FAU - Ala-Houhala, M
AU  - Ala-Houhala M
FAU - Arikoski, P
AU  - Arikoski P
FAU - Kataja, J
AU  - Kataja J
FAU - Ronnholm, K
AU  - Ronnholm K
FAU - Merenmies, J
AU  - Merenmies J
FAU - Nuutinen, M
AU  - Nuutinen M
FAU - Jahnukainen, T
AU  - Jahnukainen T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130418
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Disease Progression
MH  - Female
MH  - Finland
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Infant
MH  - Male
MH  - Nephritis, Interstitial/complications/*diagnosis/*genetics
MH  - Polymorphism, Genetic
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Risk
MH  - Uveitis/complications/*diagnosis/*genetics
EDAT- 2013/04/19 06:00
MHDA- 2014/01/05 06:00
CRDT- 2013/04/19 06:00
PHST- 2012/12/11 00:00 [received]
PHST- 2013/03/10 00:00 [revised]
PHST- 2013/03/21 00:00 [accepted]
PHST- 2013/04/19 06:00 [entrez]
PHST- 2013/04/19 06:00 [pubmed]
PHST- 2014/01/05 06:00 [medline]
AID - 10.1111/tan.12116 [doi]
PST - ppublish
SO  - Tissue Antigens. 2013 Jun;81(6):435-41. doi: 10.1111/tan.12116. Epub 2013 Apr 18.