PMID- 23594457
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20221207
IS  - 1349-3329 (Electronic)
IS  - 0040-8727 (Linking)
VI  - 229
IP  - 4
DP  - 2013 Apr
TI  - The -308G/A polymorphism of the tumor necrosis factor-alpha gene is associated 
      with the risk of upper aerodigestive tract cancer: a meta-analysis.
PG  - 245-54
AB  - Tumor necrosis factor-alpha (TNF-alpha) has been proposed to contribute to the 
      development of upper aerodigestive tract (UADT) cancer that is characterized by 
      poor prognosis. The G-to-A nucleotide change at -308 of the TNF-alpha gene (-308G/A 
      polymorphism) can increase the expression level of TNF-alpha and thus may affect the 
      genetic susceptibility of UADT cancer. The association between the -308G/A 
      polymorphism and UADT cancer has been widely studied, but the results published 
      are quite controversial. To obtain a more precise conclusion, we performed a 
      meta-analysis including 1,751 patients and 3,345 controls. The results indicated 
      that the AA genotype of the -308G/A polymorphism had a 54%-increased risk of UADT 
      cancer, compared with the G carriers (GG and GA genotypes) [odds ratio (OR) = 
      1.54, 95% confidence interval (CI): 1.07-2.21]. After stratified by ethnicity, 
      the AA genotype was associated with increased risk of UADT cancers in South 
      Asians (OR = 33.18 and 95% CI: 1.92-573.62 for AA vs. GA+GG) but not in 
      Caucasians or East Asians. After stratified by tumor site, the -308G/A 
      polymorphism was associated with increased risks of oropharynx cancer (OR = 2.68 
      and 95% CI: 1.34-5.35 for AA vs. GA+GG) but not associated with esophagus or 
      larynx cancer. After stratified by histological type, the -308G/A polymorphism 
      was associated with increased risks of squamous cell carcinoma (OR = 1.81 and 95% 
      CI: 1.15-2.84 for AA vs. GA+GG) but not associated with adenocarcinoma. Our 
      results indicate that the -308G/A polymorphism might contribute to an increased 
      risk of UADT cancer susceptibility.
FAU - Wang, Jiayi
AU  - Wang J
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, 
      Sichuan University, Chengdu, Sichuan, P.R. China.
FAU - Jin, Xin
AU  - Jin X
FAU - Wang, Hui
AU  - Wang H
FAU - Yang, Jiantang
AU  - Yang J
FAU - Wang, Lili
AU  - Wang L
FAU - Lei, Lei
AU  - Lei L
FAU - Li, Xiaoxu
AU  - Li X
FAU - Zhou, Yu
AU  - Zhou Y
FAU - Zeng, Xin
AU  - Zeng X
FAU - Jiang, Lu
AU  - Jiang L
FAU - Liao, Ga
AU  - Liao G
FAU - Dan, Hongxia
AU  - Dan H
FAU - Chen, Qianming
AU  - Chen Q
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Tohoku J Exp Med
JT  - The Tohoku journal of experimental medicine
JID - 0417355
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Asian People/genetics
MH  - Carcinoma, Squamous Cell/ethnology/*genetics
MH  - Gene Expression Regulation/*genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Humans
MH  - Odds Ratio
MH  - Pharyngeal Neoplasms/ethnology/*genetics
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics/metabolism
MH  - White People/genetics
EDAT- 2013/04/19 06:00
MHDA- 2013/10/18 06:00
CRDT- 2013/04/19 06:00
PHST- 2013/04/19 06:00 [entrez]
PHST- 2013/04/19 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - DN/JST.JSTAGE/tjem/229.245 [pii]
AID - 10.1620/tjem.229.245 [doi]
PST - ppublish
SO  - Tohoku J Exp Med. 2013 Apr;229(4):245-54. doi: 10.1620/tjem.229.245.