PMID- 23595796
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20130418
IS  - 1439-3646 (Electronic)
IS  - 0947-7349 (Linking)
VI  - 121
IP  - 4
DP  - 2013 Apr
TI  - Micro-inflammation characterized by disturbed Treg/Teff balance with increasing 
      sIL-2R in patients with type 2 diabetes.
PG  - 214-9
LID - 10.1055/s-0033-1333687 [doi]
AB  - OBJECTIVES: Type 2 diabetes mellitus (T2DM) has been gradually considered as a 
      micro- inflammatory disease. To explore the significance of peripheral CD4(+) 
      regulatory T cells and CD4(+) effector T cells in T2DM, we analyzed inflammation, 
      humoral and cellular immune state in patients with T2DM. PATIENTS AND METHODS: 
      118 patients with T2DM without complications and 116 healthy volunteers were 
      included. Serum C-reactive protein (CRP), Complement 3 (C3), Complement 4 (C4), 
      IgG, IgA, IgM, plasma sIL-2 R and peripheral T lymphocyte subsets (including 
      CD4(+)CD25(high) regulatory T cells (Treg) and CD4(+)CD25(low+median) effector T 
      cells (Teff)) were analyzed by rate nephelometry immunoassay, chemiluminescence 
      immunoassay and flow cytometry, respectively. RESULTS: (1) micro-inflammation 
      state in T2DM: Serum CRP, C3, IgA and plasma sIL-2 R were all significantly 
      higher in T2DM than those in healthy control (HC) (all P<0.05). (2) Disturbance 
      of cellular immune in T2DM: Compared with HC, the percentage of peripheral 
      CD3(+)CD4(+)T cells and ratio of CD3(+)CD4(+)T cells to CD3(+)CD8(+)T cells in 
      T2DM were both significantly increased (P<0.05); and the percentage of peripheral 
      CD4(+)CD25(+)T cells, Teff cells increased (P>0.05), Treg cells strikingly 
      decreased in T2DM (P<0.05). A positive correlation between sIL-2R levels and 
      peripheral CD4(+)CD25(+)T cells or Teff cell percentages, as well as a negative 
      correlation between plasma sIL-2 R levels and serum HDL, LDL or CHOL levels in 
      T2DM were shown (all P <0.05). CONCLUSIONS: Micro-inflammation state in T2DM was 
      characterized by increased sIL-2 R, elevated CD3(+)CD4(+)T cells and the 
      imbalance of Treg cells and Teff cells, which as one of the pathogeneses took 
      part in inflammation reaction in T2DM.
CI  - (c) J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart . New York.
FAU - Cai, B
AU  - Cai B
AD  - Department of Laboratory Medicine, West China Hospital of Sichuan University, 
      Sichuan, PR China.
FAU - Zhang, J
AU  - Zhang J
FAU - Zhang, M
AU  - Zhang M
FAU - Li, L
AU  - Li L
FAU - Feng, W
AU  - Feng W
FAU - An, Z
AU  - An Z
FAU - Wang, L
AU  - Wang L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130417
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German 
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
RN  - 0 (Complement C3)
RN  - 0 (Complement C4)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Lipids)
RN  - 0 (Receptors, Interleukin-2)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - C-Reactive Protein/analysis
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Complement C3/analysis
MH  - Complement C4/analysis
MH  - Diabetes Mellitus, Type 2/complications/*immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin A/blood
MH  - Inflammation/*complications/*immunology
MH  - Lipids/blood
MH  - Lymphocyte Count
MH  - Male
MH  - Middle Aged
MH  - Receptors, Interleukin-2/*blood
MH  - T-Lymphocyte Subsets/*immunology
MH  - T-Lymphocytes, Regulatory/*immunology
EDAT- 2013/04/19 06:00
MHDA- 2013/10/18 06:00
CRDT- 2013/04/19 06:00
PHST- 2013/04/19 06:00 [entrez]
PHST- 2013/04/19 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - 10.1055/s-0033-1333687 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 2013 Apr;121(4):214-9. doi: 10.1055/s-0033-1333687. 
      Epub 2013 Apr 17.