PMID- 23596160
OWN - NLM
STAT- MEDLINE
DCOM- 20130722
LR  - 20230216
IS  - 1541-6100 (Electronic)
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 143
IP  - 6
DP  - 2013 Jun
TI  - Grape powder supplementation prevents oxidative stress-induced anxiety-like 
      behavior, memory impairment, and high blood pressure in rats.
PG  - 835-42
LID - 10.3945/jn.113.174649 [doi]
AB  - We examined whether or not grape powder treatment ameliorates oxidative 
      stress-induced anxiety-like behavior, memory impairment, and hypertension in 
      rats. Oxidative stress in Sprague-Dawley rats was produced by using 
      L-buthionine-(S,R)-sulfoximine (BSO). Four groups of rats were used: 1) control 
      (C; injected with vehicle and provided with tap water), 2) grape powder-treated 
      (GP; injected with vehicle and provided for 3 wk with 15 g/L grape powder 
      dissolved in tap water), 3) BSO-treated [injected with BSO (300 mg/kg body 
      weight), i.p. for 7 d and provided with tap water], and 4) BSO plus grape 
      powder-treated (GP+BSO; injected with BSO and provided with grape powder-treated 
      tap water). Anxiety-like behavior was significantly greater in BSO rats compared 
      with C or GP rats (P < 0.05). Grape powder attenuated BSO-induced anxiety-like 
      behavior in GP+BSO rats. BSO rats made significantly more errors in both short- 
      and long-term memory tests compared with C or GP rats (P < 0.05), which was 
      prevented in GP+BSO rats. Systolic and diastolic blood pressure was significantly 
      greater in BSO rats compared with C or GP rats (P < 0.05), whereas grape powder 
      prevented high blood pressure in GP+BSO rats. Furthermore, brain extracellular 
      signal-regulated kinase-1/2 (ERK-1/2) was activated (P < 0.05), whereas levels of 
      glyoxalase-1 (GLO-1), glutathione reductase-1 (GSR-1), 
      calcium/calmodulin-dependent protein kinase type IV (CAMK-IV), cAMP response 
      element-binding protein (CREB), and brain-derived neurotrophic factor (BDNF) were 
      significantly less (P < 0.05) in BSO but not in GP+BSO rats compared with C or GP 
      rats. We suggest that by regulating brain ERK-1/2, GLO-1, GSR-1, CAMK-IV, CREB, 
      and BDNF levels, grape powder prevents oxidative stress-induced anxiety, memory 
      impairment, and hypertension in rats.
FAU - Allam, Farida
AU  - Allam F
AD  - Department of Pharmacological and Pharmaceutical Sciences, University of Houston, 
      Houston, TX, USA.
FAU - Dao, An T
AU  - Dao AT
FAU - Chugh, Gaurav
AU  - Chugh G
FAU - Bohat, Ritu
AU  - Bohat R
FAU - Jafri, Faizan
AU  - Jafri F
FAU - Patki, Gaurav
AU  - Patki G
FAU - Mowrey, Christopher
AU  - Mowrey C
FAU - Asghar, Mohammad
AU  - Asghar M
FAU - Alkadhi, Karim A
AU  - Alkadhi KA
FAU - Salim, Samina
AU  - Salim S
LA  - eng
GR  - R15 MH093918/MH/NIMH NIH HHS/United States
GR  - R15 G103327/PHS HHS/United States
GR  - R01 AG039836/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130417
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Polyphenols)
RN  - 5072-26-4 (Buthionine Sulfoximine)
RN  - EC 1.8.1.7 (Glutathione Reductase)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 4)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
RN  - EC 4.4.1.5 (Lactoylglutathione Lyase)
SB  - IM
MH  - Animals
MH  - Anxiety/etiology/*prevention & control
MH  - Behavior, Animal
MH  - Brain Chemistry
MH  - Brain-Derived Neurotrophic Factor/analysis
MH  - Buthionine Sulfoximine/administration & dosage
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 4/analysis
MH  - Cyclic AMP Response Element-Binding Protein/analysis
MH  - Dietary Supplements
MH  - Disease Models, Animal
MH  - Extracellular Signal-Regulated MAP Kinases/metabolism
MH  - Food, Preserved
MH  - Freeze Drying
MH  - Fruit/*chemistry
MH  - Glutathione Reductase/analysis
MH  - Hypertension/etiology/*prevention & control
MH  - Lactoylglutathione Lyase/analysis
MH  - Male
MH  - Memory Disorders/etiology/*prevention & control
MH  - Oxidative Stress/*physiology
MH  - Polyphenols/administration & dosage
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Vitis/*chemistry
PMC - PMC3652881
COIS- Author disclosures: F. Allam, A. T. Dao, G. Chugh, R. Bohat, F. Jafri, G. Patki, 
      C. Mowrey, M. Asghar, K. A. Alkadhi, and S. Salim, no conflicts of interest.
EDAT- 2013/04/19 06:00
MHDA- 2013/07/23 06:00
PMCR- 2014/06/01
CRDT- 2013/04/19 06:00
PHST- 2013/04/19 06:00 [entrez]
PHST- 2013/04/19 06:00 [pubmed]
PHST- 2013/07/23 06:00 [medline]
PHST- 2014/06/01 00:00 [pmc-release]
AID - S0022-3166(22)01206-8 [pii]
AID - 174649 [pii]
AID - 10.3945/jn.113.174649 [doi]
PST - ppublish
SO  - J Nutr. 2013 Jun;143(6):835-42. doi: 10.3945/jn.113.174649. Epub 2013 Apr 17.