PMID- 23597759 OWN - NLM STAT- MEDLINE DCOM- 20140106 LR - 20220310 IS - 1872-7972 (Electronic) IS - 0304-3940 (Linking) VI - 544 DP - 2013 Jun 7 TI - Peripheral toxicity in crack cocaine use disorders. PG - 80-4 LID - S0304-3940(13)00288-7 [pii] LID - 10.1016/j.neulet.2013.03.045 [doi] AB - A growing body of evidence suggests that crack cocaine misuse has widespread systemic and cognitive consequences, but little attention has been given to its systemic pathophysiology. We report here changes in inflammation markers, oxidative damage and brain derived neurotrophic factor in a sample of outpatients with crack cocaine use disorders. Fifty-three outpatients were recruited for this cross-sectional study and matched with fifty control subjects. The focus of this report is in between group differences in cytokines, oxidative damage and brain-derived neurotrophic factor (BDNF). Crack cocaine use was associated with higher BDNF levels when compared to controls, present only in those who used crack cocaine in the last month. Patients also had higher circulating levels of IL-1beta, TNF-alpha and IL-10 when compared to controls. There were no significant differences in oxidative damage between patients and controls. These results represent a first demonstration that crack cocaine use disorders entail an activation of the reward, immune and inflammatory systems. CI - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved. FAU - Narvaez, Joana C M AU - Narvaez JC AD - Bipolar Disorders Program & INCT Translational Medicine, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. FAU - Magalhaes, Pedro V AU - Magalhaes PV FAU - Fries, Gabriel R AU - Fries GR FAU - Colpo, Gabriela D AU - Colpo GD FAU - Czepielewski, Leticia S AU - Czepielewski LS FAU - Vianna, Priscila AU - Vianna P FAU - Chies, Jose Artur Bogo AU - Chies JA FAU - Rosa, Adriane R AU - Rosa AR FAU - Von Diemen, Lisia AU - Von Diemen L FAU - Vieta, Eduard AU - Vieta E FAU - Pechansky, Flavio AU - Pechansky F FAU - Kapczinski, Flavio AU - Kapczinski F LA - eng PT - Comparative Study PT - Journal Article DEP - 20130415 PL - Ireland TA - Neurosci Lett JT - Neuroscience letters JID - 7600130 RN - 0 (Biomarkers) RN - 0 (Crack Cocaine) RN - 0 (Cytokines) SB - IM MH - Adult MH - Biomarkers/blood MH - Brazil/epidemiology MH - Causality MH - Cocaine-Related Disorders/*blood/*epidemiology MH - Comorbidity MH - Crack Cocaine/*toxicity MH - Cytokines/*blood MH - Female MH - Humans MH - Inflammation/*blood/*epidemiology MH - Male MH - Risk Assessment MH - Risk Factors EDAT- 2013/04/20 06:00 MHDA- 2014/01/07 06:00 CRDT- 2013/04/20 06:00 PHST- 2013/02/04 00:00 [received] PHST- 2013/03/11 00:00 [revised] PHST- 2013/03/27 00:00 [accepted] PHST- 2013/04/20 06:00 [entrez] PHST- 2013/04/20 06:00 [pubmed] PHST- 2014/01/07 06:00 [medline] AID - S0304-3940(13)00288-7 [pii] AID - 10.1016/j.neulet.2013.03.045 [doi] PST - ppublish SO - Neurosci Lett. 2013 Jun 7;544:80-4. doi: 10.1016/j.neulet.2013.03.045. Epub 2013 Apr 15.