PMID- 23597829
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140224
LR  - 20160606
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 246
DP  - 2013 Aug 29
TI  - The effect of maternal infection on cognitive development and hippocampus 
      neuronal apoptosis, proliferation and differentiation in the neonatal rats.
PG  - 422-34
LID - S0306-4522(13)00339-4 [pii]
LID - 10.1016/j.neuroscience.2013.04.021 [doi]
AB  - Many epidemiological reports stated a strong association between maternal 
      infection and development of cerebral palsy, which is a major cause of cognitive 
      impairment. The pathophysiological mechanism of intrauterine inflammation is 
      complex. Recently, it was demonstrated that inflammation has a modulating effect 
      on adult neurogenesis. In this study, we discovered the effect of maternal 
      infection to hippocampal neuronal apoptosis, proliferation and differentiation, 
      and cognitive development in the developing brains of neonatal rats. Morris water 
      maze test was used to assess learning and memory. Terminal deoxynucleotidyl 
      transferase dUTP nick end labeling assay was used to determine neuronal 
      apoptosis, immunostaining was conducted to assess neurogenesis, and Western blot 
      for extracellular signal-regulated kinase (ERK), cyclic AMP responsive 
      element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) 
      expression in the hippocampus. Results demonstrated that maternal infection 
      increased neuronal apoptosis and significantly impaired spatial learning and 
      memory ability. Maternal infection significantly increased cell proliferation, 
      accompanied by an increased expression of ERK (P3-P7), CREB (P3-P7) and BDNF 
      (P3). On P28, there was no significant difference of cell survival and 
      differentiation in two groups. These results suggest that variation in ERK 
      activity and subsequent expression of its downstream targets, including CREB and 
      BDNF might contribute, at least partially, to modulation of inflammation related 
      cell proliferation, survival and differentiation. Maternal infection increased 
      hippocampal neuronal apoptosis and affected cell proliferation and 
      differentiation in neonatal rats, which may be regarded as an etiological factor 
      in cognitive development impairment.
CI  - Copyright (c) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Jiang, P F
AU  - Jiang PF
AD  - Department of Neurology, Children's Hospital, School of Medicine, Zhejiang 
      University, Hangzhou 310003, China.
FAU - Zhu, T
AU  - Zhu T
FAU - Gao, J D
AU  - Gao JD
FAU - Gao, F
AU  - Gao F
FAU - Mao, S S
AU  - Mao SS
FAU - Zhao, W T
AU  - Zhao WT
FAU - Gu, W Z
AU  - Gu WZ
FAU - Yu, H M
AU  - Yu HM
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20130415
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RIN - Neuroscience. 2013 Dec 19;254:476. PMID: 24527492
EDAT- 2013/04/20 06:00
MHDA- 2013/04/20 06:01
CRDT- 2013/04/20 06:00
PHST- 2013/01/26 00:00 [received]
PHST- 2013/04/04 00:00 [revised]
PHST- 2013/04/05 00:00 [accepted]
PHST- 2013/04/20 06:00 [entrez]
PHST- 2013/04/20 06:00 [pubmed]
PHST- 2013/04/20 06:01 [medline]
AID - S0306-4522(13)00339-4 [pii]
AID - 10.1016/j.neuroscience.2013.04.021 [doi]
PST - ppublish
SO  - Neuroscience. 2013 Aug 29;246:422-34. doi: 10.1016/j.neuroscience.2013.04.021. 
      Epub 2013 Apr 15.