PMID- 23598622
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130422
LR  - 20211021
IS  - 0161-9152 (Print)
IS  - 1574-4647 (Electronic)
IS  - 0161-9152 (Linking)
VI  - 27
IP  - 2
DP  - 2005 Jun
TI  - Mouse liver plasma membrane redox system activity is altered by aging and 
      modulated by calorie restriction.
PG  - 153-60
LID - 10.1007/s11357-005-2726-3 [doi]
AB  - Caloric restriction (CR) is known as the only non-genetic method proven to slow 
      the rate of aging and extend lifespan in animals. Free radicals production 
      emerges from normal metabolic activity and generates the accumulation of oxidized 
      macromolecules, one of the main characteristics of aging. Due to its central role 
      in cell bioenergetics, a great interest has been paid to CR-induced modifications 
      in mitochondria, where CR has been suggested to decrease reactive oxygen species 
      production. The plasma membrane contains a trans-membrane redox system (PMRS) 
      that provides electrons to recycle lipophilic antioxidants, such as alpha-tocopherol 
      and coenzyme Q (CoQ), and to modulate cytosolic redox homeostasis. In the present 
      study, we have investigated age differences in the PMRS in mouse liver and their 
      modulation by CR. Aging induced a decrease in the ratio of CoQ10/CoQ9 and 
      alpha-tocopherol in liver PM from AL-fed mice that was attenuated by CR. 
      CoQ-dependent NAD(P)H dehydrogenases highly increased in CR old mice liver PMs. 
      On the other hand, the CoQ-independent NADH-FCN reductase activity increased in 
      AL-fed animals; whereas, in mice under CR this activity did not change during 
      aging. Our results suggest that liver PMRS activity changes during aging and that 
      CR modulates these changes. By this mechanism CR maintains a higher antioxidant 
      capacity in liver PM of old animals by increasing the activity of CoQ-dependent 
      reductases. Also, the putative role of PMRS in the modulation of redox 
      homeostasis of cytosol is implicated.
FAU - Lopez-Lluch, G
AU  - Lopez-Lluch G
AD  - Laboratorio Andaluz de Biologia, Universidad Pablo de Olavide, Carretera de 
      Utrera km 1, 41013 Sevilla, Spain.
FAU - Rios, M
AU  - Rios M
FAU - Lane, M A
AU  - Lane MA
FAU - Navas, P
AU  - Navas P
FAU - de Cabo, R
AU  - de Cabo R
LA  - eng
PT  - Journal Article
DEP - 20051210
PL  - Netherlands
TA  - Age (Dordr)
JT  - Age (Dordrecht, Netherlands)
JID - 101250497
PMC - PMC3458500
OTO - NOTNLM
OT  - cytochrome b5 reductase
OT  - plasma membrane redox system
OT  - quinone reductase
OT  - ubiquinone
EDAT- 2005/06/01 00:00
MHDA- 2005/06/01 00:01
PMCR- 2006/06/01
CRDT- 2013/04/20 06:00
PHST- 2005/04/21 00:00 [received]
PHST- 2005/08/14 00:00 [revised]
PHST- 2005/08/22 00:00 [accepted]
PHST- 2013/04/20 06:00 [entrez]
PHST- 2005/06/01 00:00 [pubmed]
PHST- 2005/06/01 00:01 [medline]
PHST- 2006/06/01 00:00 [pmc-release]
AID - 22726 [pii]
AID - 10.1007/s11357-005-2726-3 [doi]
PST - ppublish
SO  - Age (Dordr). 2005 Jun;27(2):153-60. doi: 10.1007/s11357-005-2726-3. Epub 2005 Dec 
      10.