PMID- 23599872
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130422
LR  - 20220410
IS  - 1948-9358 (Print)
IS  - 1948-9358 (Electronic)
IS  - 1948-9358 (Linking)
VI  - 4
IP  - 2
DP  - 2013 Apr 15
TI  - Parental transmission of type 2 diabetes mellitus in a highly endogamous 
      population.
PG  - 40-6
LID - 10.4239/wjd.v4.i2.40 [doi]
AB  - AIM: To determine the parental transmission of diabetes mellitus (DM) and 
      evaluate its influence on the clinical characteristics. METHODS: This was a cross 
      sectional study. The survey was carried out in urban and semi-urban primary 
      health care centers. Of the 2400 registered with diagnosed diabetes, 1980 agreed 
      and gave their consent to take part in this study, thus giving a response rate of 
      82.5%. Face to face interviews were conducted using a structured questionnaire 
      followed by laboratory tests. DM was defined according to the World Health 
      Organization expert group. A trained nurse performed physical examinations and 
      measurements. RESULTS: Of the study population, 72.9% reported a family history 
      of DM. Family history of DM was significantly higher in females (54.2%; P = 0.04) 
      and in the age group below 30 years (24%; P < 0.001). The prevalence of diabetes 
      was higher among patients with a diabetic mother (25.4% vs 22.1%) and maternal 
      aunts/uncles (31.2% vs 22.2%) compared to patients with a diabetic father and 
      paternal aunts/uncles. Family history of DM was higher in patients of 
      consanguineous parents (38.5%) than those of non-consanguineous parents (30.2%). 
      The development of type 2 diabetes mellitus (T2DM) complications was higher in 
      patients with either a paternal or maternal history of DM than in those without. 
      No significant difference was observed in the metabolic characteristics of 
      patients with/without family history of DM except for hypertension. Complications 
      were higher in diabetic patients with a family history of DM. CONCLUSION: The 
      present study found a significant maternal effect in transmission of T2DM. Family 
      history is associated with the increased incidence of diabetes.
FAU - Bener, Abdulbari
AU  - Bener A
AD  - Abdulbari Bener, Mohammad T Yousafzai, Department of Medical Statistics and 
      Epidemiology, Hamad Medical Corporation, Doha 3050, Qatar.
FAU - Yousafzai, Mohammad T
AU  - Yousafzai MT
FAU - Al-Hamaq, Abdulla Oaa
AU  - Al-Hamaq AO
FAU - Mohammad, Abdul-Ghani
AU  - Mohammad AG
FAU - Defronzo, Ralph A
AU  - Defronzo RA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Diabetes
JT  - World journal of diabetes
JID - 101547524
PMC - PMC3629295
OTO - NOTNLM
OT  - Consanguinity
OT  - Diabetes mellitus
OT  - Family history
OT  - Genetic disorders
OT  - Maternal transmission
OT  - Parental transmission
EDAT- 2013/04/20 06:00
MHDA- 2013/04/20 06:01
PMCR- 2013/04/15
CRDT- 2013/04/20 06:00
PHST- 2012/12/05 00:00 [received]
PHST- 2013/03/06 00:00 [revised]
PHST- 2013/03/15 00:00 [accepted]
PHST- 2013/04/20 06:00 [entrez]
PHST- 2013/04/20 06:00 [pubmed]
PHST- 2013/04/20 06:01 [medline]
PHST- 2013/04/15 00:00 [pmc-release]
AID - 10.4239/wjd.v4.i2.40 [doi]
PST - ppublish
SO  - World J Diabetes. 2013 Apr 15;4(2):40-6. doi: 10.4239/wjd.v4.i2.40.