PMID- 23600729 OWN - NLM STAT- MEDLINE DCOM- 20140929 LR - 20230921 IS - 1600-0838 (Electronic) IS - 0905-7188 (Linking) VI - 24 IP - 1 DP - 2014 Feb TI - The effects of physical activity and exercise on brain-derived neurotrophic factor in healthy humans: A review. PG - 1-10 LID - 10.1111/sms.12069 [doi] AB - The purpose of this study was to summarize the effects of physical activity and exercise on peripheral brain-derived neurotrophic factor (BDNF) in healthy humans. Experimental and observational studies were identified from PubMed, Web of Knowledge, Scopus, and SPORT Discus. A total of 32 articles met the inclusion criteria. Evidence from experimental studies suggested that peripheral BDNF concentrations were elevated by acute and chronic aerobic exercise. The majority of the studies suggested that strength training had no influence on peripheral BDNF. The results from most observational studies suggested an inverse relationship between the peripheral BDNF level and habitual physical activity or cardiorespiratory fitness. More research is needed to confirm the findings from the observational studies. CI - (c) 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. FAU - Huang, T AU - Huang T AD - Centre of Research in Childhood Health, Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. FAU - Larsen, K T AU - Larsen KT FAU - Ried-Larsen, M AU - Ried-Larsen M FAU - Moller, N C AU - Moller NC FAU - Andersen, L B AU - Andersen LB LA - eng PT - Journal Article PT - Review DEP - 20130422 PL - Denmark TA - Scand J Med Sci Sports JT - Scandinavian journal of medicine & science in sports JID - 9111504 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Brain-Derived Neurotrophic Factor/*blood MH - Cognition/*physiology MH - Exercise/*physiology MH - Humans MH - Motor Activity/*physiology MH - Physical Fitness/*physiology MH - Resistance Training OTO - NOTNLM OT - brain-derived neurotrophic factor OT - cardiorespiratory fitness OT - cognitive function OT - exercise OT - physical activity EDAT- 2013/04/23 06:00 MHDA- 2014/09/30 06:00 CRDT- 2013/04/23 06:00 PHST- 2013/01/24 00:00 [accepted] PHST- 2013/04/23 06:00 [entrez] PHST- 2013/04/23 06:00 [pubmed] PHST- 2014/09/30 06:00 [medline] AID - 10.1111/sms.12069 [doi] PST - ppublish SO - Scand J Med Sci Sports. 2014 Feb;24(1):1-10. doi: 10.1111/sms.12069. Epub 2013 Apr 22.