PMID- 23600996
OWN - NLM
STAT- MEDLINE
DCOM- 20141114
LR  - 20131224
IS  - 1943-3670 (Electronic)
IS  - 0022-3492 (Linking)
VI  - 85
IP  - 1
DP  - 2014 Jan
TI  - Clinical correlates of a lateral-flow immunoassay oral risk indicator.
PG  - 188-94
LID - 10.1902/jop.2013.130116 [doi]
AB  - BACKGROUND: The aim of the present study is to investigate the clinical 
      correlates of a novel lateral-flow immunoassay with bleeding on probing (BOP), 
      oral hygiene, and periodontal probing depth. This report offers a simple, rapid, 
      and highly sensitive tool that addresses two issues important to periodontists: 
      1) detecting active periodontitis, and 2) predicting chronic periodontitis. 
      METHODS: Seventy-six of 86 males requiring seminal fluid analysis as part of a 
      separate study were serially recruited into the study. After basic dental and 
      periodontal examination under natural light and with the use of the community 
      periodontal index of treatment needs (CPITN) probe, debris and calculus indices 
      were recorded per participant. Participants were subsequently grouped into 
      "good," "fair," and "poor" oral hygiene categories based on a simplified oral 
      hygiene index. BOP was assessed with the ball-ended tip of the probe, and 
      periodontitis was assessed with pocket probing as well as a lateral flow of 
      neutrophil collagenase-2 immunoassay, which measures levels of matrix 
      metalloproteinase-8. RESULTS: Neutrophil collagenase-2 immunoassay was 96% 
      sensitive for poor oral hygiene, 95% sensitive for chronic periodontitis (defined 
      as at least two sites with periodontal pockets), and 82.6% sensitive for at least 
      two sites with BOP. CONCLUSION: Neutrophil collagenase-2 immunoassay had a high 
      sensitivity for at least two sites with BOP and two sites with periodontal 
      pockets but a lower relationship for single-site pockets and BOP.
FAU - Nwhator, S O
AU  - Nwhator SO
AD  - Department of Preventive Dentistry, University of Abuja Teaching Hospital, 
      Federal Capital Territory, Abuja, Nigeria.
FAU - Ayanbadejo, P O
AU  - Ayanbadejo PO
FAU - Umeizudike, K A
AU  - Umeizudike KA
FAU - Opeodu, O I
AU  - Opeodu OI
FAU - Agbelusi, G A
AU  - Agbelusi GA
FAU - Olamijulo, J A
AU  - Olamijulo JA
FAU - Arowojolu, M O
AU  - Arowojolu MO
FAU - Sorsa, T
AU  - Sorsa T
FAU - Babajide, B S
AU  - Babajide BS
FAU - Opedun, D O
AU  - Opedun DO
LA  - eng
PT  - Journal Article
DEP - 20130419
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
RN  - 0 (Reagent Kits, Diagnostic)
RN  - EC 3.4.24.34 (Matrix Metalloproteinase 8)
SB  - IM
MH  - Chronic Periodontitis/etiology
MH  - Dental Calculus/classification
MH  - Forecasting
MH  - Humans
MH  - Immunoenzyme Techniques/methods
MH  - Male
MH  - Matrix Metalloproteinase 8/*analysis
MH  - Oral Hygiene
MH  - Oral Hygiene Index
MH  - Patient Acuity
MH  - Periodontal Index
MH  - Periodontal Pocket/classification
MH  - Periodontitis/*diagnosis/enzymology
MH  - Reagent Kits, Diagnostic
MH  - Sensitivity and Specificity
EDAT- 2013/04/23 06:00
MHDA- 2014/11/15 06:00
CRDT- 2013/04/23 06:00
PHST- 2013/04/23 06:00 [entrez]
PHST- 2013/04/23 06:00 [pubmed]
PHST- 2014/11/15 06:00 [medline]
AID - 10.1902/jop.2013.130116 [doi]
PST - ppublish
SO  - J Periodontol. 2014 Jan;85(1):188-94. doi: 10.1902/jop.2013.130116. Epub 2013 Apr 
      19.