PMID- 23601576
OWN - NLM
STAT- MEDLINE
DCOM- 20130913
LR  - 20220311
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Linking)
VI  - 112
IP  - 2
DP  - 2013 Jul 15
TI  - Usefulness of monocyte chemoattractant protein-1 to predict no-reflow and 
      three-year mortality in patients with ST-segment elevation myocardial infarction 
      undergoing primary percutaneous coronary intervention.
PG  - 187-93
LID - S0002-9149(13)00807-2 [pii]
LID - 10.1016/j.amjcard.2013.03.011 [doi]
AB  - Although monocyte chemoattractant protein-1 (MCP-1) levels are increased in 
      patients with ST-segment elevation myocardial infarction, the prognostic value of 
      MCP-1 in primary percutaneous coronary intervention (pPCI) is not clear. The goal 
      of the present study was to investigate the association of MCP-1 levels with 
      myocardial perfusion and prognosis in patients with ST-segment elevation 
      myocardial infarction undergoing pPCI. Consecutive pPCI patients (n = 192) were 
      assigned to tertiles according to their admission serum MCP-1 levels. 
      Angiographic no-reflow, Thrombolysis In Myocardial Infarction flow grade, 
      myocardial blush grade, and ST-segment resolution were assessed. Mortality and 
      major adverse cardiac events were evaluated during hospitalization and at the 
      3-year clinical follow-up visit. Failure of ST resolution was associated with 
      greater admission MCP-1 levels. The risk of no-reflow (Thrombolysis In Myocardial 
      Infarction flow </=2 or Thrombolysis In Myocardial Infarction flow 3 with final 
      myocardial blush grade </=2 after pPCI and ST resolution <30%) increased as the 
      admission MCP-1 increased. The 3-year mortality increased as the MCP-1 level 
      increased (8% vs 22% vs 28% for the 3 tertiles, p <0.01). Multivariate logistic 
      regression analysis demonstrated that MCP-1 levels at admission are a significant 
      independent correlate of 3-year mortality in patients with no-reflow as detected 
      by myocardial blush grade. A receiver operating characteristics analysis 
      identified an optimum cut point of >/=254 pg/ml, which was associated with a 
      negative predictive value of 95% in association with 1-year mortality. In 
      conclusion, the plasma MCP-1 levels at admission are independently associated 
      with the development of no-reflow and 3-year mortality in patients with 
      ST-segment elevation myocardial infarction undergoing pPCI.
CI  - Crown Copyright (c) 2013. Published by Elsevier Inc. All rights reserved.
FAU - Buyukkaya, Eyup
AU  - Buyukkaya E
AD  - Department of Cardiology, Mustafa Kemal University, Tayfur Ata Sokmen Medical 
      School, Hatay, Turkey.
FAU - Poyraz, Fatih
AU  - Poyraz F
FAU - Karakas, Mehmet F
AU  - Karakas MF
FAU - Kurt, Mustafa
AU  - Kurt M
FAU - Akcay, Adnan B
AU  - Akcay AB
FAU - Akpinar, Ibrahim
AU  - Akpinar I
FAU - Motor, Sedat
AU  - Motor S
FAU - Turak, Osman
AU  - Turak O
FAU - Ozturk, Oktay H
AU  - Ozturk OH
FAU - Sen, Nihat
AU  - Sen N
FAU - Akpek, Mahmut
AU  - Akpek M
FAU - Kaya, Mehmet G
AU  - Kaya MG
FAU - Gibson, C Michael
AU  - Gibson CM
LA  - eng
PT  - Journal Article
DEP - 20130418
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/blood/*mortality/*surgery
MH  - No-Reflow Phenomenon/*blood/*mortality
MH  - *Percutaneous Coronary Intervention
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Time Factors
EDAT- 2013/04/23 06:00
MHDA- 2013/09/14 06:00
CRDT- 2013/04/23 06:00
PHST- 2013/01/13 00:00 [received]
PHST- 2013/03/14 00:00 [revised]
PHST- 2013/03/14 00:00 [accepted]
PHST- 2013/04/23 06:00 [entrez]
PHST- 2013/04/23 06:00 [pubmed]
PHST- 2013/09/14 06:00 [medline]
AID - S0002-9149(13)00807-2 [pii]
AID - 10.1016/j.amjcard.2013.03.011 [doi]
PST - ppublish
SO  - Am J Cardiol. 2013 Jul 15;112(2):187-93. doi: 10.1016/j.amjcard.2013.03.011. Epub 
      2013 Apr 18.