PMID- 23601655
OWN - NLM
STAT- MEDLINE
DCOM- 20130906
LR  - 20130624
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 156
IP  - 1
DP  - 2013 Jul
TI  - Near-infrared and short-wavelength autofluorescence in resolved central serous 
      chorioretinopathy: association with outer retinal layer abnormalities.
PG  - 157-164.e2
LID - S0002-9394(13)00143-8 [pii]
LID - 10.1016/j.ajo.2013.02.016 [doi]
AB  - PURPOSE: To evaluate the correlation between changes in fundus autofluorescence 
      (AF) measured using 2 different sources (near-infrared fundus autofluorescence 
      from melanin and short-wavelength fundus autofluorescence from lipofuscin) with 
      changes in spectral-domain optical coherence tomography (SD OCT) and fluorescein 
      angiography in resolved central serous chorioretinopathy (CSC). DESIGN: 
      Retrospective, observational case study. METHODS: A total of 91 eyes from 86 
      patients with a history of resolved CSC and abnormal AF imaging findings were 
      included. In addition to AF, patients were assessed by means of SD OCT and 
      fluorescein angiography. Outer retinal layer alterations in OCT images and 
      abnormalities in fluorescein angiography were analyzed and correlated with the 
      corresponding AF data. RESULTS: All eyes with abnormal near-infrared AF showed a 
      hyperfluorescent angiography window defect in the corresponding area. There was a 
      significant association between the OCT and short-wavelength AF findings. An 
      abnormal short-wavelength AF signal was significantly associated with loss of the 
      ellipsoid portion of the inner segments (EPIS, previously known as the junction 
      between the inner and outer segments of the photoreceptors) on SD OCT (chi(2) test; 
      P < .0001). Near-infrared AF could not predict the status of EPIS without the 
      short-wavelength AF image. CONCLUSIONS: Outer retinal layer changes in OCT images 
      can be predicted by analyzing both short-wavelength AF and near-infrared AF 
      images. Abnormal changes in the short-wavelength AF image were predictive of EPIS 
      damage.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Kim, Sang-Kyoon
AU  - Kim SK
AD  - Department of Ophthalmology, Korea University College of Medicine, Seoul, South 
      Korea.
FAU - Kim, Seong-Woo
AU  - Kim SW
FAU - Oh, Jaeryung
AU  - Oh J
FAU - Huh, Kuhl
AU  - Huh K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130417
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
RN  - 0 (Lipofuscin)
RN  - 0 (Melanins)
SB  - IM
MH  - Adult
MH  - Central Serous Chorioretinopathy/*diagnosis/metabolism
MH  - Female
MH  - Fluorescein Angiography
MH  - Fluorescence
MH  - Humans
MH  - Infrared Rays
MH  - Lipofuscin/metabolism
MH  - Male
MH  - Melanins/metabolism
MH  - Radio Waves
MH  - Retinal Photoreceptor Cell Inner Segment/*pathology
MH  - Retinal Photoreceptor Cell Outer Segment/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
EDAT- 2013/04/23 06:00
MHDA- 2013/09/07 06:00
CRDT- 2013/04/23 06:00
PHST- 2012/11/21 00:00 [received]
PHST- 2013/02/21 00:00 [revised]
PHST- 2013/02/22 00:00 [accepted]
PHST- 2013/04/23 06:00 [entrez]
PHST- 2013/04/23 06:00 [pubmed]
PHST- 2013/09/07 06:00 [medline]
AID - S0002-9394(13)00143-8 [pii]
AID - 10.1016/j.ajo.2013.02.016 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2013 Jul;156(1):157-164.e2. doi: 10.1016/j.ajo.2013.02.016. Epub 
      2013 Apr 17.