PMID- 23602088
OWN - NLM
STAT- MEDLINE
DCOM- 20140203
LR  - 20221207
IS  - 1873-4588 (Electronic)
IS  - 0892-1997 (Linking)
VI  - 27
IP  - 4
DP  - 2013 Jul
TI  - Prevalence of laryngopharyngeal reflux disease in patients with diabetes 
      mellitus.
PG  - 495-9
LID - S0892-1997(12)00111-7 [pii]
LID - 10.1016/j.jvoice.2012.07.010 [doi]
AB  - OBJECTIVE: To study the prevalence of laryngopharyngeal reflux disease (LPRD) in 
      patients with type 2 diabetes mellitus (T2DM) and report the correlation between 
      LPRD and glycemic control, duration of the disease, and presence of neuropathy. 
      MATERIALS AND METHODS: This is a cross-sectional study of 100 patients with T2DM 
      and 33 controls matched according to age and gender. The reflux symptom index 
      (RSI) was used to assess the presence of LPRD. A score greater than 10 was 
      considered diagnostic of LPRD. RESULTS: Twenty-two percent of patients with T2DM 
      had RSI above 10 versus 9.1% of controls. The difference was not statistically 
      different (P value of 0.100). The average score of all symptoms of LPRD was 
      higher in the diabetic group compared with the control group. There was a 
      significant increase in the average score of "throat clearing" and "lump 
      sensation in throat," with a borderline significant increase in "annoying cough" 
      in patients with diabetes versus controls (respective P values of 0.03, 0.025, 
      and 0.066). There was no correlation between LPRD and any of the demographic 
      variables except neuropathy. CONCLUSION: Patients with T2DM are more likely to 
      have LPRD compared with controls. However, the prevalence of LPRD is not 
      significantly higher in diabetic patients compared with controls. When present, 
      LPRD correlates with neuropathy. LEVEL OF EVIDENCE: 2c.
CI  - Copyright (c) 2013 The Voice Foundation. Published by Mosby, Inc. All rights 
      reserved.
FAU - Hamdan, Abdul-latif
AU  - Hamdan AL
AD  - Department of Otolaryngology and Head and Neck Surgery, American University of 
      Beirut Medical Center, New York, NY 10017, USA.
FAU - Jabbour, Jad
AU  - Jabbour J
FAU - Barazi, Randa
AU  - Barazi R
FAU - Korban, Zeina
AU  - Korban Z
FAU - Azar, Sami T
AU  - Azar ST
LA  - eng
PT  - Journal Article
DEP - 20130416
PL  - United States
TA  - J Voice
JT  - Journal of voice : official journal of the Voice Foundation
JID - 8712262
RN  - 0 (Biomarkers)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/diagnosis/drug therapy/*epidemiology
MH  - Diabetic Neuropathies/epidemiology
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Laryngopharyngeal Reflux/diagnosis/*epidemiology/therapy
MH  - Male
MH  - Middle Aged
MH  - New York City/epidemiology
MH  - Prevalence
MH  - Young Adult
EDAT- 2013/04/23 06:00
MHDA- 2014/02/04 06:00
CRDT- 2013/04/23 06:00
PHST- 2012/02/24 00:00 [received]
PHST- 2012/07/12 00:00 [accepted]
PHST- 2013/04/23 06:00 [entrez]
PHST- 2013/04/23 06:00 [pubmed]
PHST- 2014/02/04 06:00 [medline]
AID - S0892-1997(12)00111-7 [pii]
AID - 10.1016/j.jvoice.2012.07.010 [doi]
PST - ppublish
SO  - J Voice. 2013 Jul;27(4):495-9. doi: 10.1016/j.jvoice.2012.07.010. Epub 2013 Apr 
      16.