PMID- 23602498 OWN - NLM STAT- MEDLINE DCOM- 20140108 LR - 20220311 IS - 1872-6623 (Electronic) IS - 0304-3959 (Linking) VI - 154 IP - 6 DP - 2013 Jun TI - Efficacy of melatonin in the treatment of endometriosis: a phase II, randomized, double-blind, placebo-controlled trial. PG - 874-81 LID - S0304-3959(13)00081-X [pii] LID - 10.1016/j.pain.2013.02.025 [doi] AB - Endometriosis-associated chronic pelvic pain (EACPP) presents with an intense inflammatory reaction. Melatonin has emerged as an important analgesic, antioxidant, and antiinflammatory agent. This trial investigates the effects of melatonin compared with a placebo on EACPP, brain-derived neurotrophic factor (BDNF) level, and sleep quality. Forty females, aged 18 to 45 years, were randomized into the placebo (n = 20) or melatonin (10 mg) (n = 20) treatment groups for a period of 8 weeks. There was a significant interaction (time vs group) regarding the main outcomes of the pain scores as indexed by the visual analogue scale on daily pain, dysmenorrhea, dysuria, and dyschezia (analysis of variance, P < 0.01 for all analyses). Post hoc analysis showed that compared with placebo, the treatment reduced daily pain scores by 39.80% (95% confidence interval [CI] 12.88-43.01%) and dysmenorrhea by 38.01% (95% CI 15.96-49.15%). Melatonin improved sleep quality, reduced the risk of using an analgesic by 80%, and reduced BNDF levels independently of its effect on pain. This study provides additional evidence regarding the analgesic effects of melatonin on EACPP and melatonin's ability to improve sleep quality. Additionally, the study revealed that melatonin modulates the secretion of BDNF and pain through distinct mechanisms. CI - Copyright (c) 2013 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved. FAU - Schwertner, Andre AU - Schwertner A AD - Laboratory of Pain & Neuromodulation at Hospital de Clinicas de Porto Alegre (HCPA)/Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. FAU - Conceicao Dos Santos, Claudia C AU - Conceicao Dos Santos CC FAU - Costa, Gislene Dalferth AU - Costa GD FAU - Deitos, Alicia AU - Deitos A FAU - de Souza, Andressa AU - de Souza A FAU - de Souza, Izabel Cristina Custodio AU - de Souza IC FAU - Torres, Iraci L S AU - Torres IL FAU - da Cunha Filho, Joao Sabino L AU - da Cunha Filho JS FAU - Caumo, Wolnei AU - Caumo W LA - eng PT - Clinical Trial, Phase II PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20130305 PL - United States TA - Pain JT - Pain JID - 7508686 RN - 0 (Analgesics) RN - JL5DK93RCL (Melatonin) SB - IM CIN - Pain. 2013 Jun;154(6):775. PMID: 23582150 MH - Adolescent MH - Adult MH - Analgesics/pharmacology/therapeutic use MH - Double-Blind Method MH - Dysmenorrhea/*drug therapy MH - Endometriosis/*drug therapy MH - Female MH - Humans MH - Melatonin/pharmacology/*therapeutic use MH - Middle Aged MH - Ovarian Diseases/*drug therapy MH - Pain Measurement MH - Pelvic Pain/*drug therapy MH - Sleep/drug effects MH - Treatment Outcome EDAT- 2013/04/23 06:00 MHDA- 2014/01/09 06:00 CRDT- 2013/04/23 06:00 PHST- 2012/09/11 00:00 [received] PHST- 2013/02/07 00:00 [revised] PHST- 2013/02/22 00:00 [accepted] PHST- 2013/04/23 06:00 [entrez] PHST- 2013/04/23 06:00 [pubmed] PHST- 2014/01/09 06:00 [medline] AID - S0304-3959(13)00081-X [pii] AID - 10.1016/j.pain.2013.02.025 [doi] PST - ppublish SO - Pain. 2013 Jun;154(6):874-81. doi: 10.1016/j.pain.2013.02.025. Epub 2013 Mar 5.