PMID- 23602881
OWN - NLM
STAT- MEDLINE
DCOM- 20131031
LR  - 20130729
IS  - 1532-821X (Electronic)
IS  - 0003-9993 (Linking)
VI  - 94
IP  - 8
DP  - 2013 Aug
TI  - Effects of physical exercise on plasma levels of brain-derived neurotrophic 
      factor and depressive symptoms in elderly women--a randomized clinical trial.
PG  - 1443-50
LID - S0003-9993(13)00307-9 [pii]
LID - 10.1016/j.apmr.2013.03.029 [doi]
AB  - OBJECTIVES: To investigate the effect of 2 standardized exercise programs, muscle 
      strength exercises (SE) and aerobic exercises (AE), on the plasma levels of 
      brain-derived neurotrophic factor (BDNF) and depressive symptoms in 451 elderly 
      women. DESIGN: A randomized controlled trial. SETTING: Belo Horizonte/MG-Brazil. 
      PARTICIPANTS: Community-dwelling older women (N=451; age, 65-89y). INTERVENTION: 
      The participants were divided into 2 groups: SE and AE. Both protocols lasted 10 
      weeks, and 30 sessions (1-h sessions) in total were performed 3 times a week 
      under the direct supervision of physical therapists. MAIN OUTCOME MEASURES: 
      Plasma levels of BDNF (enzyme-linked immunosorbent assay) and depressive symptoms 
      (Geriatric Depression Scale). RESULTS: There was a significant difference for 
      BDNF plasma levels between the SE and AE groups (P=.009). Post hoc analysis 
      revealed a pre-post intervention difference in BDNF levels only for the SE group 
      (P=.008). A statistically significant difference was found for the pre- and 
      postintervention Geriatric Depression Scale scores in both groups (P=.001), 
      showing that the effects of both exercise protocols were comparable regarding 
      depressive symptoms (P=.185). CONCLUSIONS: The present findings have demonstrated 
      the positive effect of muscle strengthening and aerobic intervention on 
      depressive symptoms in community-dwelling elderly women. Interestingly, only SE 
      significantly increased the plasma levels of BDNF in our sample. The positive 
      effects of physical exercise on depressive symptoms in the elderly were not 
      mediated by BDNF.
CI  - Copyright (c) 2013 American Congress of Rehabilitation Medicine. Published by 
      Elsevier Inc. All rights reserved.
FAU - Pereira, Daniele S
AU  - Pereira DS
AD  - Programa de Pos-Graduacao em Ciencias da Reabilitacao, Departamento de 
      Fisioterapia, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, 
      Brazil. daniele.sirineu@gmail.com
FAU - de Queiroz, Barbara Z
AU  - de Queiroz BZ
FAU - Miranda, Aline S
AU  - Miranda AS
FAU - Rocha, Natalia P
AU  - Rocha NP
FAU - Felicio, Diogo C
AU  - Felicio DC
FAU - Mateo, Elvis C
AU  - Mateo EC
FAU - Favero, Michelle
AU  - Favero M
FAU - Coelho, Fernanda M
AU  - Coelho FM
FAU - Jesus-Moraleida, Fabianna
AU  - Jesus-Moraleida F
FAU - Gomes Pereira, Danielle A
AU  - Gomes Pereira DA
FAU - Teixeira, Antonio L
AU  - Teixeira AL
FAU - Maximo Pereira, Leani S
AU  - Maximo Pereira LS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20130418
PL  - United States
TA  - Arch Phys Med Rehabil
JT  - Archives of physical medicine and rehabilitation
JID - 2985158R
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Brazil
MH  - Cohort Studies
MH  - Depressive Disorder/*blood/*rehabilitation
MH  - *Exercise
MH  - Female
MH  - Humans
MH  - Sex Factors
OTO - NOTNLM
OT  - AE
OT  - BDNF
OT  - Brain-derived neurotrophic factor
OT  - Depression
OT  - Elderly
OT  - Exercise
OT  - GDS
OT  - Geriatric Depression Scale
OT  - RM
OT  - Rehabilitation
OT  - Repetition Maximum
OT  - SE
OT  - aerobic exercises
OT  - brain-derived neurotrophic factor
OT  - muscle exercises
EDAT- 2013/04/23 06:00
MHDA- 2013/11/01 06:00
CRDT- 2013/04/23 06:00
PHST- 2013/01/16 00:00 [received]
PHST- 2013/03/29 00:00 [revised]
PHST- 2013/03/29 00:00 [accepted]
PHST- 2013/04/23 06:00 [entrez]
PHST- 2013/04/23 06:00 [pubmed]
PHST- 2013/11/01 06:00 [medline]
AID - S0003-9993(13)00307-9 [pii]
AID - 10.1016/j.apmr.2013.03.029 [doi]
PST - ppublish
SO  - Arch Phys Med Rehabil. 2013 Aug;94(8):1443-50. doi: 10.1016/j.apmr.2013.03.029. 
      Epub 2013 Apr 18.