PMID- 23602987
OWN - NLM
STAT- MEDLINE
DCOM- 20140806
LR  - 20131209
IS  - 1873-7064 (Electronic)
IS  - 0028-3908 (Linking)
VI  - 76 Pt C
DP  - 2014 Jan
TI  - BDNF-induced local protein synthesis and synaptic plasticity.
PG  - 639-56
LID - S0028-3908(13)00142-1 [pii]
LID - 10.1016/j.neuropharm.2013.04.005 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is an important regulator of synaptic 
      transmission and long-term potentiation (LTP) in the hippocampus and in other 
      brain regions, playing a role in the formation of certain forms of memory. The 
      effects of BDNF in LTP are mediated by TrkB (tropomyosin-related kinase B) 
      receptors, which are known to be coupled to the activation of the Ras/ERK, 
      phosphatidylinositol 3-kinase/Akt and phospholipase C-gamma (PLC-gamma) pathways. The 
      role of BDNF in LTP is best studied in the hippocampus, where the neurotrophin 
      acts at pre- and post-synaptic levels. Recent studies have shown that BDNF 
      regulates the transport of mRNAs along dendrites and their translation at the 
      synapse, by modulating the initiation and elongation phases of protein synthesis, 
      and by acting on specific miRNAs. Furthermore, the effect of BDNF on 
      transcription regulation may further contribute to long-term changes in the 
      synaptic proteome. In this review we discuss the recent progress in understanding 
      the mechanisms contributing to the short- and long-term regulation of the 
      synaptic proteome by BDNF, and the role in synaptic plasticity, which is likely 
      to influence learning and memory formation. This article is part of the Special 
      Issue entitled 'BDNF Regulation of Synaptic Structure, Function, and Plasticity'.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Leal, Graciano
AU  - Leal G
AD  - CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 
      Coimbra, Portugal; Department of Life Sciences, University of Coimbra, 3004-517 
      Coimbra, Portugal.
FAU - Comprido, Diogo
AU  - Comprido D
FAU - Duarte, Carlos B
AU  - Duarte CB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130416
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism/pharmacology
MH  - Humans
MH  - Neuronal Plasticity/*physiology
MH  - Protein Biosynthesis/drug effects/*physiology
MH  - Receptor, trkB/metabolism
MH  - Signal Transduction/drug effects/*physiology
MH  - Synaptic Transmission/*physiology
OTO - NOTNLM
OT  - 4EBP
OT  - A2RE
OT  - ADF
OT  - AS
OT  - Arc
OT  - BDNF
OT  - Brain-derived neurotrophic factor (BDNF)
OT  - CPE
OT  - CPEB
OT  - CREB
OT  - CYFIP1
OT  - Ca(2+)- and calmodulin-dependent protein kinase II
OT  - Ca(2+)- and calmodulin-dependent protein kinase kinase
OT  - CaMKII
OT  - CaMKK
OT  - DG
OT  - E-LTP
OT  - EJC
OT  - FMRP
OT  - GIPC1
OT  - GRIP1
OT  - HFS
OT  - IEG
OT  - IP3
OT  - IRES
OT  - L-LTP
OT  - LIM domain kinase 1
OT  - LIMK1
OT  - LTP
OT  - Long-term potentiation (LTP)
OT  - MAP
OT  - MAPK and ERK kinase, type 1/2
OT  - MEK1/2
OT  - MSK1
OT  - NT-4
OT  - P-bodies
OT  - PAK
OT  - PDZ (postsynaptic density-95/Discs large/zona occludens-1) domain-containing 
      adaptor protein, type 1
OT  - PH domain
OT  - PI3-K
OT  - PICK1
OT  - PLC-gamma
OT  - PSD
OT  - PSD95
OT  - PSF
OT  - Pum2
OT  - RISC
OT  - RNA processing bodies
OT  - RNA transport
OT  - RNA-induced silencing complex
OT  - Rab3a interacting molecule 1alpha
OT  - Rim1alpha
OT  - SAM68
OT  - SAP97
OT  - Src-associated in mitosis of 68 kDa
OT  - Synaptic plasticity
OT  - TORC
OT  - TRPC3
OT  - Translation
OT  - TrkB
OT  - ZBP1
OT  - actin-depolymerizing factor
OT  - activity-regulated cytoskeleton-associated protein
OT  - antisense
OT  - brain-derived neurotrophic factor
OT  - cAMP-response element-binding protein
OT  - cytoplasmic Fmr-interacting protein 1
OT  - cytoplasmic polyadenylation element
OT  - cytoplasmic polyadenylation element-binding protein
OT  - dentate gyrus
OT  - eEF
OT  - eIF
OT  - eIF4E-binding protein
OT  - early-LTP
OT  - eukaryotic elongation factor
OT  - eukaryotic initiation factor
OT  - exon junction complex
OT  - fragile X mental retardation protein
OT  - glutamate receptor-interacting protein 1
OT  - heterogeneous nuclear ribonucleoprotein
OT  - heterogeneous nuclear ribonucleoprotein (hnRNP) A2 response element
OT  - high-frequency stimulation
OT  - hnRNP
OT  - immediate-early genes
OT  - inositol 1,4,5-trisphosphate
OT  - internal ribosomal entry site
OT  - late-LTP
OT  - long-term potentiation
OT  - mRNPs
OT  - mTOR
OT  - mammalian target of rapamycin
OT  - messenger ribonucleoprotein complexes
OT  - microtubule-associated protein
OT  - mitogen- and stress-activated kinase 1
OT  - neurotrophin-4
OT  - p21-activated kinase
OT  - phosphatidylinositol 3-kinase
OT  - phospholipase C-gamma
OT  - pleckstrin homology domain
OT  - polypyrimidine tract binding protein-associated splicing factor
OT  - postsynaptic density
OT  - postsynaptic density protein 95
OT  - protein interacting with C kinase 1
OT  - pumilio2
OT  - synapse-associated protein 97
OT  - target of rapamycin (TOR) complex
OT  - transient receptor-potential cation channel subfamily C (TRPC), type 3
OT  - tropomyosin-related kinase B
OT  - zipcode-binding protein 1
EDAT- 2013/04/23 06:00
MHDA- 2014/08/07 06:00
CRDT- 2013/04/23 06:00
PHST- 2013/02/02 00:00 [received]
PHST- 2013/03/25 00:00 [revised]
PHST- 2013/04/03 00:00 [accepted]
PHST- 2013/04/23 06:00 [entrez]
PHST- 2013/04/23 06:00 [pubmed]
PHST- 2014/08/07 06:00 [medline]
AID - S0028-3908(13)00142-1 [pii]
AID - 10.1016/j.neuropharm.2013.04.005 [doi]
PST - ppublish
SO  - Neuropharmacology. 2014 Jan;76 Pt C:639-56. doi: 
      10.1016/j.neuropharm.2013.04.005. Epub 2013 Apr 16.