PMID- 23603311
OWN - NLM
STAT- MEDLINE
DCOM- 20131212
LR  - 20130527
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 74
IP  - 7
DP  - 2013 Jul
TI  - Genetic variants in interleukin-18 gene and risk for cervical squamous cell 
      carcinoma.
PG  - 882-7
LID - S0198-8859(13)00087-6 [pii]
LID - 10.1016/j.humimm.2013.04.001 [doi]
AB  - Cervical cancer is strongly associated with infection of oncogenic types of human 
      papillomavirus (HPV). However, HPV infection alone is not sufficient for 
      progression to cervical cancer. It is now recognized that host immunogenetic 
      background participates in the control of HPV infection and development of 
      cervical cancer. Interleukin-18 (IL-18) is a multifunctional cytokine that 
      induces interferon-gamma secretion and plays a central role in antitumor 
      immunity. The aim of this study is to determine if potentially functional 
      polymorphisms in IL-18 gene are associated with risk of HPV-induced cervical 
      cancer in Taiwanese women. Pre-Developed TaqMan Allelic Discrimination Assay was 
      used to genotype IL-18 -1297 T/C, -607 C/A, -380 C/G, -137 G/C, and +105 A/C 
      polymorphisms in a hospital-based study of 470 women with cervical squamous cell 
      carcinoma (CSCC) and 722 age-matched healthy control women. The presence and 
      genotypes of HPV in CSCC was determined by PCR. None of the polymorphisms or any 
      haplotype was found to have significant differences in distribution among all 
      subjects with CSCC, those with HPV-16 positive CSCC, and controls. Our results 
      suggest that the IL-18 -1297 T/C, -607 C/A, -380 C/G, -137 G/C, and +105 A/C 
      polymorphisms are not associated with susceptibility to CSCC in Taiwanese women.
CI  - Copyright (c) 2013 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Yang, Yuh-Cheng
AU  - Yang YC
AD  - Department of Gynecology and Obstetrics, Mackay Memorial Hospital, Taipei City, 
      Taiwan.
FAU - Chang, Tzu-Yang
AU  - Chang TY
FAU - Chen, Tze-Chien
AU  - Chen TC
FAU - Chang, Shih-Chuan
AU  - Chang SC
FAU - Lin, Wen-Shan
AU  - Lin WS
FAU - Lee, Yann-Jinn
AU  - Lee YJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130417
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Carcinoma, Squamous Cell/etiology/*genetics/immunology
MH  - DNA Mutational Analysis
MH  - Disease Susceptibility
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Middle Aged
MH  - Papillomaviridae/*immunology
MH  - Papillomavirus Infections/complications/*genetics/immunology
MH  - Polymorphism, Genetic
MH  - Risk
MH  - Taiwan
MH  - Uterine Cervical Neoplasms/etiology/*genetics/immunology
EDAT- 2013/04/23 06:00
MHDA- 2013/12/18 06:00
CRDT- 2013/04/23 06:00
PHST- 2012/11/16 00:00 [received]
PHST- 2013/01/31 00:00 [revised]
PHST- 2013/04/09 00:00 [accepted]
PHST- 2013/04/23 06:00 [entrez]
PHST- 2013/04/23 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - S0198-8859(13)00087-6 [pii]
AID - 10.1016/j.humimm.2013.04.001 [doi]
PST - ppublish
SO  - Hum Immunol. 2013 Jul;74(7):882-7. doi: 10.1016/j.humimm.2013.04.001. Epub 2013 
      Apr 17.