PMID- 23603442
OWN - NLM
STAT- MEDLINE
DCOM- 20140919
LR  - 20220129
IS  - 1878-3627 (Electronic)
IS  - 0922-6028 (Linking)
VI  - 32
IP  - 1
DP  - 2014
TI  - Neuroplasticity and memory formation in major depressive disorder: an imaging 
      genetics perspective on serotonin and BDNF.
PG  - 25-49
LID - 10.3233/RNN-139005 [doi]
AB  - A vast number of imaging studies have demonstrated the impact of serotonin (5-HT) 
      and brain-derived neurotrophic factor (BDNF) on emotion and memory-related 
      networks in the context of Major Depressive Disorder (MDD). Underlying molecular 
      mechanisms that affect the functionality of these networks have been examined in 
      detail in animals and corroborate imaging findings. The crucial role of 5-HT and 
      BDNF signaling in the context of MDD is reflected in the etiologic models of MDD 
      such as the monoamine or neuroplasticity hypothesis as well as in pharmacological 
      models of antidepressant response. While antidepressant drug treatment has been 
      primarily linked to the modulation of emotion-related networks, cognitive 
      behavioral therapy has been implicated in a top-down control of limbic 
      structures. Initially, a simple lack of monoamines or BDNF has been proposed as 
      causal factor of MDD etiology. However, recent findings suggest a much more 
      complex neurobiology emphasizing epistatic and epigenetic mechanisms responsible 
      for structural and functional changes observed in emotion and memory-related 
      brain regions of healthy subjects and MDD patients. In this review, which focuses 
      on neuroimaging studies in the context of MDD, the authors will provide a 
      comprehensive overview of these networks as well as on the specific role of 5-HT 
      and BDNF in their development and function.
FAU - Kuhn, Manuel
AU  - Kuhn M
AD  - Division of Biological Psychiatry, Department of Psychiatry and Psychotherapy, 
      Medical University of Vienna, Waehringer Guertel Vienna, Austria.
FAU - Popovic, Ana
AU  - Popovic A
AD  - Division of Biological Psychiatry, Department of Psychiatry and Psychotherapy, 
      Medical University of Vienna, Waehringer Guertel Vienna, Austria.
FAU - Pezawas, Lukas
AU  - Pezawas L
AD  - Division of Biological Psychiatry, Department of Psychiatry and Psychotherapy, 
      Medical University of Vienna, Waehringer Guertel Vienna, Austria.
LA  - eng
GR  - KLI 148/FWF_/Austrian Science Fund FWF/Austria
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Restor Neurol Neurosci
JT  - Restorative neurology and neuroscience
JID - 9005499
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Brain/pathology
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - *Depressive Disorder, Major/genetics/pathology/physiopathology
MH  - Humans
MH  - Memory/*physiology
MH  - Neuroimaging
MH  - Neuronal Plasticity/*physiology
MH  - Serotonin/*genetics/metabolism
OTO - NOTNLM
OT  - BDNF
OT  - Neuroimaging
OT  - SLC6A4
OT  - epistasis
OT  - functional magnetic resonance imaging
OT  - learning
OT  - major depressive disorder
OT  - memory
OT  - neuroplasticity
OT  - selective serotonin re-uptake inhibitor
OT  - serotonin transporter
OT  - tryptophan
EDAT- 2013/04/23 06:00
MHDA- 2014/09/23 06:00
CRDT- 2013/04/23 06:00
PHST- 2013/04/23 06:00 [entrez]
PHST- 2013/04/23 06:00 [pubmed]
PHST- 2014/09/23 06:00 [medline]
AID - 37L437105524X420 [pii]
AID - 10.3233/RNN-139005 [doi]
PST - ppublish
SO  - Restor Neurol Neurosci. 2014;32(1):25-49. doi: 10.3233/RNN-139005.