PMID- 23604965
OWN - NLM
STAT- MEDLINE
DCOM- 20140429
LR  - 20220310
IS  - 1476-3524 (Electronic)
IS  - 1029-8428 (Linking)
VI  - 24
IP  - 4
DP  - 2013 Nov
TI  - Altered cytokine and BDNF levels in autism spectrum disorder.
PG  - 491-501
LID - 10.1007/s12640-013-9393-4 [doi]
AB  - The contribution of neuroimmune functioning and brain-derived neurotrophic factor 
      (BDNF) to functional dysregulation in autism spectrum disorder was assessed in 29 
      patients under treatment in two specialized centers of Basilicata (Chiaromonte 
      and Matera), Southern Italy, through analysis of serum levels of cytokines and 
      BDNF. Elevated levels of the pro-inflammatory cytokine, including interleukin-1, 
      interleukin-6, interleukin-12, interleukin-23, tumor necrosis factor-alpha and BDNF 
      were observed, regardless of age and gender. Comparisons were made with age- and 
      gender-related healthy controls. The present findings reinforce current notions 
      regarding immunoexcitotoxic mechanisms contributing to the pathophysiology of 
      autistic disorder.
FAU - Ricci, S
AU  - Ricci S
AD  - Department of Anatomy, Histology, Legal Medicine and Orthopaedics, Sapienza 
      University, Viale Regina Elena, 336, 00161, Rome, Italy, 
      serafino.ricci@uniroma1.it.
FAU - Businaro, R
AU  - Businaro R
FAU - Ippoliti, F
AU  - Ippoliti F
FAU - Lo Vasco, V R
AU  - Lo Vasco VR
FAU - Massoni, F
AU  - Massoni F
FAU - Onofri, E
AU  - Onofri E
FAU - Troili, G M
AU  - Troili GM
FAU - Pontecorvi, V
AU  - Pontecorvi V
FAU - Morelli, M
AU  - Morelli M
FAU - Rapp Ricciardi, M
AU  - Rapp Ricciardi M
FAU - Archer, T
AU  - Archer T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130419
PL  - United States
TA  - Neurotox Res
JT  - Neurotoxicity research
JID - 100929017
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 187348-17-0 (Interleukin-12)
SB  - IM
MH  - Adolescent
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Child
MH  - Child Development Disorders, Pervasive/blood/*immunology
MH  - Child, Preschool
MH  - Cytokines/*blood
MH  - Female
MH  - Humans
MH  - Interleukin-1/blood
MH  - Interleukin-12/blood
MH  - Interleukin-6/blood
MH  - Male
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2013/04/23 06:00
MHDA- 2014/04/30 06:00
CRDT- 2013/04/23 06:00
PHST- 2012/07/30 00:00 [received]
PHST- 2013/04/10 00:00 [accepted]
PHST- 2013/04/09 00:00 [revised]
PHST- 2013/04/23 06:00 [entrez]
PHST- 2013/04/23 06:00 [pubmed]
PHST- 2014/04/30 06:00 [medline]
AID - 10.1007/s12640-013-9393-4 [doi]
PST - ppublish
SO  - Neurotox Res. 2013 Nov;24(4):491-501. doi: 10.1007/s12640-013-9393-4. Epub 2013 
      Apr 19.