PMID- 23605335
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130423
LR  - 20211021
IS  - 0178-7888 (Print)
IS  - 0178-7888 (Linking)
VI  - 21
IP  - 3
DP  - 2005 Sep
TI  - In vitro induction of tumor necrosis factor-alpha by ochratoxin A (OTA) from rat 
      liver: role of Kupffer cells.
PG  - 172-5
LID - 10.1007/BF02959257 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) is released from blood-free perfused rat liver by 
      the fungal metabolite ochratoxin A. Here we have identified Kupffer cells as the 
      sole source of OTA-mediated cytokine release. If single cell preparation of 
      Kupffer cells, hepatocytes, or sinusoidal endothelial cells were prepared from 
      rat livers, only Kupffer cells released TNF-alpha upon incubation with 2.5 mumol/l 
      OTA. OTA failed to induce TNF-alpha release in the blood-free perfused isolated rat 
      liver when Kupffer cells were blockedin vitro by 15 mumol/l gadolinium chloride. 
      When rats were pretreatedin vivo with the Kupffer cell depleting clodronate 
      liposomes, OTA-mediated TNF-alpha release was abrogated in the isolated perfused 
      liver model.
FAU - Al-Anati, L
AU  - Al-Anati L
AD  - Faculty of Veterinary Medicine, Institute of Pharmacology and Toxicology, 
      Justus-Liebig-University Giessen, Frankfurters Strasse 107, 35392, Giessen, 
      Germany.
FAU - Reinehr, R
AU  - Reinehr R
FAU - Van Rooijen, N
AU  - Van Rooijen N
FAU - Petzinger, E
AU  - Petzinger E
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Mycotoxin Res
JT  - Mycotoxin research
JID - 8807334
EDAT- 2005/09/01 00:00
MHDA- 2005/09/01 00:01
CRDT- 2013/04/23 06:00
PHST- 2013/04/23 06:00 [entrez]
PHST- 2005/09/01 00:00 [pubmed]
PHST- 2005/09/01 00:01 [medline]
AID - 10.1007/BF02959257 [doi]
PST - ppublish
SO  - Mycotoxin Res. 2005 Sep;21(3):172-5. doi: 10.1007/BF02959257.