PMID- 2360543
OWN - NLM
STAT- MEDLINE
DCOM- 19900801
LR  - 20180330
IS  - 0002-9165 (Print)
IS  - 0002-9165 (Linking)
VI  - 52
IP  - 1
DP  - 1990 Jul
TI  - Consequences of severe copper deficiency are independent of dietary carbohydrate 
      in young pigs.
PG  - 147-54
AB  - The ability of carbohydrates (CHO), such as fructose and sucrose, to aggravate 
      copper deficiency in rats and the recent dietary trends of Western human 
      populations led to the suggestion that the Cu X CHO interaction may be pertinent 
      to public health. This hypothesis was tested with pigs because their 
      cardiovascular and gastrointestinal systems closely resemble those of humans. 
      Weanling pigs were fed a diet containing either 59% sucrose or cornstarch with 
      either deficient (0.8 mg/kg diet) or adequate (6.4 mg/kg) copper for 10 wk. 
      Plasma and tissue copper, the activities of plasma ceruloplasmin ferroxidase and 
      erythrocyte Cu,Zn-superoxide dismutase, hematocrits, and serum cholesterol and 
      triglyceride were all decreased (p less than 0.05) and relative cardiac mass was 
      increased (p less than 0.05) by severe dietary copper deficiency. The type of 
      dietary CHO did not differentially influence the values of these variables. Thus, 
      these data fail to support the hypothesis that the Cu X CHO interaction observed 
      in rats represents a health risk for humans.
FAU - Schoenemann, H M
AU  - Schoenemann HM
AD  - Vitamin and Mineral Nutrition Laboratory, US Department of Agriculture, 
      Beltsville, MD 20705.
FAU - Failla, M L
AU  - Failla ML
FAU - Steele, N C
AU  - Steele NC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Clin Nutr
JT  - The American journal of clinical nutrition
JID - 0376027
RN  - 0 (Dietary Carbohydrates)
RN  - 57-50-1 (Sucrose)
RN  - 789U1901C5 (Copper)
RN  - 9005-25-8 (Starch)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Copper/administration & dosage/*deficiency/pharmacokinetics
MH  - Dietary Carbohydrates/administration & dosage/*metabolism
MH  - Female
MH  - Heart/drug effects
MH  - Hematocrit
MH  - Male
MH  - Organ Size/drug effects
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Starch/administration & dosage
MH  - Sucrose/administration & dosage
MH  - Swine
MH  - Tissue Distribution
EDAT- 1990/07/01 00:00
MHDA- 1990/07/01 00:01
CRDT- 1990/07/01 00:00
PHST- 1990/07/01 00:00 [pubmed]
PHST- 1990/07/01 00:01 [medline]
PHST- 1990/07/01 00:00 [entrez]
AID - 10.1093/ajcn/52.1.147 [doi]
PST - ppublish
SO  - Am J Clin Nutr. 1990 Jul;52(1):147-54. doi: 10.1093/ajcn/52.1.147.