PMID- 23607183
OWN - NLM
STAT- MEDLINE
DCOM- 20130924
LR  - 20221207
IS  - 0042-8450 (Print)
IS  - 0042-8450 (Linking)
VI  - 70
IP  - 2
DP  - 2013 Feb
TI  - Body weight and waist circumference as predictors of vitamin D deficiency in 
      patients with type 2 diabetes and cardiovascular disease.
PG  - 163-9
AB  - BACKGROUND/AIM: Vitamin D deficiency is a well-established risk factor for bone 
      disease, but emerging data suggest that altered vitamin D homeostasis may play a 
      role in the development of type 2 diabetes mellitus (T2DM), dyslipidemia 
      hypertension, and other cardiovascular diseases (CVD). The aim of this study was 
      to investigate the prevalence of vitamin D deficiency in patients with T2DM 
      with/without CVD, to correlate it with anthropometric and metabolic parameters 
      and to determine the predictors of vitamin D deficiency. METHODS: A total of 88 
      patients with T2DM (49 male/39 female, aged 61.0 +/- 0.9 yrs, body mass index 
      (BMI) 29.9 +/- 0.4 kg/m2) and 67 patients (44 male/23 female, aged 63.6 +/- 1.0 
      yrs, BMI 29.2 +/- 0.5 kg/m2) with T2DM and CVD (myocardial infarction in 57 
      patients and angina pectoris in 10 patients) were included in this study. These 
      patients were compared with 87 healthy subjects (35 male/52 female, aged 52.8 +/- 
      1.4 yrs, BMI 27.2 +/- 0.5 kg/m2). Weight, height, waist circumference and BMI 
      were recorded in all patients. Also, total cholesterol, triglycerides, hemoglobin 
      A1c (HbA1c) and 25-hydroxy-vitamin D [25(OH)D] levels were measured in all. 
      According to 25(OH)D level, all subjects were divided into three categories: 
      severe vitamin D deficiency (< or = 15 ng/mL), vitamin D insufficiency (15-20 
      ng/mL) and vitamin D sufficiency (?20 ng/mL). We correlated vitamin D levels with 
      anthropometric and metabolic status and determined the predictors of vitamin D 
      deficiency. RESULTS: Severe vitamin D deficiency was registered in 16.1% healthy 
      subjects, in 21.6% patients with T2DM and in 26.9% patients with T2DM and CVD. 
      Patients with T2DM who were vitamin D deficient had increased weight, waist 
      circumference, cholesterol and triglyceride levels when compared with patients 
      with T2DM who had sufficient vitamin D level. 25(OH)D levels correlated with BMI 
      and waist circumference in all subjects, but did not correlate with metabolic 
      parameters (lipids, HbA1c). The best predictors of vitamin D level in all 
      subjects were weight, waist circumference and BMI. CONCLUSION: The high 
      prevalence of vitamin D deficiency in patients with T2DM and particularly in 
      patients with T2DM and CVD suggests that supplementation with vitamin D may be 
      beneficial although there is still not sufficient evidence for recommending 
      prescribing vitamin D.
FAU - Kavaric, Sreten
AU  - Kavaric S
AD  - Clinic of Internal Medicine, Clinical Center Montenegro, Podgorica, Montenegro. 
      skavaric@t-com.me
FAU - Vuksanovic, Milica
AU  - Vuksanovic M
FAU - Bozovic, Dragica
AU  - Bozovic D
FAU - Jovanovic, Marko
AU  - Jovanovic M
FAU - Jeremic, Veljko
AU  - Jeremic V
FAU - Radojicic, Zoran
AU  - Radojicic Z
FAU - Pekic, Sandra
AU  - Pekic S
FAU - Popovic, Vera
AU  - Popovic V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Serbia
TA  - Vojnosanit Pregl
JT  - Vojnosanitetski pregled
JID - 21530700R
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Lipid A)
SB  - IM
MH  - Body Mass Index
MH  - *Body Weight
MH  - Cardiovascular Diseases/blood/*complications
MH  - Diabetes Mellitus, Type 2/blood/*complications
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Lipid A/blood
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Vitamin D Deficiency/complications/diagnosis
MH  - *Waist Circumference
EDAT- 2013/04/24 06:00
MHDA- 2013/09/26 06:00
CRDT- 2013/04/24 06:00
PHST- 2013/04/24 06:00 [entrez]
PHST- 2013/04/24 06:00 [pubmed]
PHST- 2013/09/26 06:00 [medline]
AID - 10.2298/vsp110713035k [doi]
PST - ppublish
SO  - Vojnosanit Pregl. 2013 Feb;70(2):163-9. doi: 10.2298/vsp110713035k.