PMID- 23607950
OWN - NLM
STAT- MEDLINE
DCOM- 20130808
LR  - 20130423
IS  - 1008-8830 (Print)
IS  - 1008-8830 (Linking)
VI  - 15
IP  - 4
DP  - 2013 Apr
TI  - [Changes in serum insulin-like growth factor-1 and insulin-like growth 
      factor-binding protein-3, and their significance in children with left-to-right 
      shunt congenital heart disease associated with heart failure].
PG  - 277-80
AB  - OBJECTIVE: To investigate changes in serum insulin-like growth factor-1 (IGF-1) 
      and insulin-like growth factor-binding protein-3 (IGFBP-3) and their significance 
      in children with left-to-right shunt congenital heart disease (CHD) associated 
      with heart failure (HF). METHODS: Twenty healthy children (control group), 20 
      children with HF, without basic heart disease (HF group), 20 children with 
      left-to-right shunt CHD, without HF (CHD group), and 30 children with 
      left-to-right shunt CHD associated with HF (CHD+HF group) were included in the 
      study. These groups were compared in terms of serum IGF-1 and IGFBP-3 levels. 
      According to the New York Heart Association (NYHA) Functional Classification, the 
      CHD+HF group was further divided into NYHA-II, NYHA-III and NYHA-IV subgroups and 
      the subgroups were compared in terms of serum IGF-1, IGFBP-3, and cardiac 
      troponin I (cTnI) levels. The correlation of serum IGF-1 and IGFBP-3 levels with 
      serum cTnI level in the CHD+HF group was analyzed. RESULTS: The CHD group showed 
      decreased serum IGF-1 and IGFBP-3 levels compared with the control group 
      (P<0.01). The CHD+HF group showed a significantly decreased serum IGF-1 level 
      compared with the control group (P<0.01) and CHD group (P<0.05). The HF group had 
      significantly increased serum IGF-1 and IGFBP-3 levels compared with other groups 
      (P<0.01). The NYHA-II subgroup had the highest serum IGF-1 level and the NYHA-IV 
      subgroup had the lowest serum IGF-1 level (P<0.01). In the CHD+HF group, serum 
      IGF-1 and IGFBP-3 levels were negatively correlated with serum cTnI level 
      (r=-0.692, P<0.05; r=-0.530, P<0.05). CONCLUSIONS: Serum IGF-1 level can be used 
      as an objective condition evaluation indicator for CHD, and low serum IGF-1 level 
      is a risk factor for HF. This also provides a clinical basis for treatment of HF 
      using exogenous IGF-1.
FAU - Peng, Jing
AU  - Peng J
AD  - Department of Cardiology, Wuhan Medical Care Center for Women and Children, 
      Wuhan, China.
FAU - Fu, Jia
AU  - Fu J
FAU - Deng, Shu-Zhen
AU  - Deng SZ
FAU - Wang, Rui-Geng
AU  - Wang RG
FAU - Liu, Ling
AU  - Liu L
FAU - Sun, Dong-Ming
AU  - Sun DM
FAU - Xia, Kun
AU  - Xia K
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Dang Dai Er Ke Za Zhi
JT  - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
JID - 100909956
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 0 (Troponin I)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Child, Preschool
MH  - Female
MH  - Heart Defects, Congenital/*blood
MH  - Heart Failure/*blood
MH  - Humans
MH  - Infant
MH  - Insulin-Like Growth Factor Binding Protein 3/*blood
MH  - Insulin-Like Growth Factor I/*analysis
MH  - Male
MH  - Troponin I/blood
EDAT- 2013/04/24 06:00
MHDA- 2013/08/09 06:00
CRDT- 2013/04/24 06:00
PHST- 2013/04/24 06:00 [entrez]
PHST- 2013/04/24 06:00 [pubmed]
PHST- 2013/08/09 06:00 [medline]
AID - 10.7499/j.issn.1008-8830.2013.04.008 [pii]
PST - ppublish
SO  - Zhongguo Dang Dai Er Ke Za Zhi. 2013 Apr;15(4):277-80.