PMID- 23608593
OWN - NLM
STAT- MEDLINE
DCOM- 20140410
LR  - 20211021
IS  - 1556-3871 (Electronic)
IS  - 1547-5271 (Print)
IS  - 1547-5271 (Linking)
VI  - 10
IP  - 8
DP  - 2013 Aug
TI  - Feasibility of image-based simulation to estimate ablation target in human 
      ventricular arrhythmia.
PG  - 1109-16
LID - S1547-5271(13)00437-2 [pii]
LID - 10.1016/j.hrthm.2013.04.015 [doi]
AB  - BACKGROUND: Previous studies suggest that magnetic resonance imaging with late 
      gadolinium enhancement (LGE) may identify slowly conducting tissues in 
      scar-related ventricular tachycardia (VT). OBJECTIVE: To test the feasibility of 
      image-based simulation based on LGE to estimate ablation targets in VT. METHODS: 
      We conducted a retrospective study in 13 patients who had preablation magnetic 
      resonance imaging for scar-related VT ablation. We used image-based simulation to 
      induce VT and estimate target regions according to the simulated VT circuit. The 
      estimated target regions were coregistered with the LGE scar map and the ablation 
      sites from the electroanatomical map in the standard ablation approach. RESULTS: 
      In image-based simulation, VT was inducible in 12 (92.3%) patients. All VTs 
      showed macroreentrant propagation patterns, and the narrowest width of estimated 
      target region that an ablation line should span to prevent VT recurrence was 5.0 
      +/- 3.4 mm. Of 11 patients who underwent ablation, the results of image-based 
      simulation and the standard approach were consistent in 9 (82%) patients, where 
      ablation within the estimated target region was associated with acute success (n 
      = 8) and ablation outside the estimated target region was associated with failure 
      (n = 1). In 1 (9%) case, the results of image-based simulation and the standard 
      approach were inconsistent, where ablation outside the estimated target region 
      was associated with acute success. CONCLUSIONS: The image-based simulation can be 
      used to estimate potential ablation targets of scar-related VT. The image-based 
      simulation may be a powerful noninvasive tool for preprocedural planning of 
      ablation procedures to potentially reduce the procedure time and complication 
      rates.
CI  - Copyright (c) 2013 Heart Rhythm Society. Published by Elsevier Inc. All rights 
      reserved.
FAU - Ashikaga, Hiroshi
AU  - Ashikaga H
AD  - Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, 
      Maryland 21287, USA. hashika1@jhmi.edu
FAU - Arevalo, Hermenegild
AU  - Arevalo H
FAU - Vadakkumpadan, Fijoy
AU  - Vadakkumpadan F
FAU - Blake, Robert C 3rd
AU  - Blake RC 3rd
FAU - Bayer, Jason D
AU  - Bayer JD
FAU - Nazarian, Saman
AU  - Nazarian S
FAU - Muz Zviman, M
AU  - Muz Zviman M
FAU - Tandri, Harikrishna
AU  - Tandri H
FAU - Berger, Ronald D
AU  - Berger RD
FAU - Calkins, Hugh
AU  - Calkins H
FAU - Herzka, Daniel A
AU  - Herzka DA
FAU - Trayanova, Natalia A
AU  - Trayanova NA
FAU - Halperin, Henry R
AU  - Halperin HR
LA  - eng
GR  - R01 HL082729/HL/NHLBI NIH HHS/United States
GR  - R01 HL094610/HL/NHLBI NIH HHS/United States
GR  - R01-HL082729/HL/NHLBI NIH HHS/United States
GR  - R01-HL094610/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130419
PL  - United States
TA  - Heart Rhythm
JT  - Heart rhythm
JID - 101200317
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
CIN - Heart Rhythm. 2013 Aug;10(8):1117-8. PMID: 23665385
MH  - Aged
MH  - Catheter Ablation/*methods
MH  - Cicatrix/*surgery
MH  - Computer Simulation
MH  - Feasibility Studies
MH  - Female
MH  - *Gadolinium
MH  - Heart Ventricles/*surgery
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Tachycardia, Ventricular/*surgery
PMC - PMC3735782
MID - NIHMS471455
OTO - NOTNLM
OT  - 3-D
OT  - 3-dimensional
OT  - Cardiac MRI
OT  - Catheter ablation
OT  - Computer simulation
OT  - ECG
OT  - EPS
OT  - HZ
OT  - ICD
OT  - Image-based simulation
OT  - LGE
OT  - LV
OT  - MI
OT  - MRI
OT  - SI
OT  - VT
OT  - Ventricular arrhythmia
OT  - electrocardiogram/electrocardiographic
OT  - electrophysiology study
OT  - heterogeneous zone
OT  - implantable cardioverter-defibrillator
OT  - late gadolinium enhancement
OT  - left ventricular
OT  - magnetic resonance imaging
OT  - myocardial infarction
OT  - signal intensity
OT  - ventricular tachycardia
EDAT- 2013/04/24 06:00
MHDA- 2014/04/11 06:00
PMCR- 2014/08/01
CRDT- 2013/04/24 06:00
PHST- 2013/01/28 00:00 [received]
PHST- 2013/04/24 06:00 [entrez]
PHST- 2013/04/24 06:00 [pubmed]
PHST- 2014/04/11 06:00 [medline]
PHST- 2014/08/01 00:00 [pmc-release]
AID - S1547-5271(13)00437-2 [pii]
AID - 10.1016/j.hrthm.2013.04.015 [doi]
PST - ppublish
SO  - Heart Rhythm. 2013 Aug;10(8):1109-16. doi: 10.1016/j.hrthm.2013.04.015. Epub 2013 
      Apr 19.