PMID- 23609397
OWN - NLM
STAT- MEDLINE
DCOM- 20131107
LR  - 20161125
IS  - 1533-712X (Electronic)
IS  - 0271-0749 (Linking)
VI  - 33
IP  - 3
DP  - 2013 Jun
TI  - Interaction between novelty seeking and the aldehyde dehydrogenase 2 gene in 
      heroin-dependent patients.
PG  - 386-90
LID - 10.1097/JCP.0b013e3182900fb3 [doi]
AB  - OBJECTIVES: Heroin dependence is a multifactor disorder. We investigated the 
      association of genetic factors and heroin-dependent temperaments to determine 
      whether a temperament-gene interaction is involved in the pathogenesis of heroin 
      dependence. METHODS: Three hundred seventy participants (259 heroin-dependent 
      patients and 111 healthy controls) were recruited and finished the Tridimensional 
      Personality Questionnaire to assess personality traits (temperament). The 
      genotypes of the aldehyde dehydrogenase 2 (ALDH2) gene and the Val66Met 
      polymorphism of the brain-derived neurotrophic factor (BDNF) gene using 
      polymerase chain reactions plus restriction fragment length polymorphism 
      analysis. RESULTS: Multiple logistic regression analysis showed significant main 
      effects for novelty seeking (P </= 0.001) and harm-avoidance (P = 0.001) scores, 
      and a significant interaction effect between novelty seeking and ALDH2 genotypes 
      (P = 0.016) in heroin-dependent patients compared with controls. When stratified 
      by the ALDH2 genotypes, only heroin-dependent patients with the *1*2 and *2*2 
      genotypes at ALDH2 had higher novelty-seeking scores than did controls (heroin 
      dependence = 15.94, controls = 12.46; P </= 0.001). CONCLUSIONS: Our results 
      provide initial evidence that the ALDH2 gene interacted with novelty seeking in 
      heroin-dependent Han Chinese patients in Taiwan.
FAU - Lee, Sheng-Yu
AU  - Lee SY
AD  - Department of Psychiatry, College of Medicine, National Cheng Kung University, 
      Tainan, Taiwan.
FAU - Wang, Tzu-Yun
AU  - Wang TY
FAU - Chen, Shiou-Lan
AU  - Chen SL
FAU - Huang, San-Yuan
AU  - Huang SY
FAU - Tzeng, Nian-Sheng
AU  - Tzeng NS
FAU - Chang, Yun-Hsuan
AU  - Chang YH
FAU - Wang, Chen-Lin
AU  - Wang CL
FAU - Wang, Yu-Shan
AU  - Wang YS
FAU - Lee, I Hui
AU  - Lee IH
FAU - Yeh, Tzung Lieh
AU  - Yeh TL
FAU - Yang, Yen Kuang
AU  - Yang YK
FAU - Lu, Ru-Band
AU  - Lu RB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Psychopharmacol
JT  - Journal of clinical psychopharmacology
JID - 8109496
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 1.2.1.3 (ALDH2 protein, human)
RN  - EC 1.2.1.3 (Aldehyde Dehydrogenase)
RN  - EC 1.2.1.3 (Aldehyde Dehydrogenase, Mitochondrial)
SB  - IM
MH  - Adult
MH  - Aldehyde Dehydrogenase/*genetics
MH  - Aldehyde Dehydrogenase, Mitochondrial
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - *Exploratory Behavior
MH  - Female
MH  - Genotype
MH  - Heroin Dependence/*genetics
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Personality Inventory
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
MH  - Polymorphism, Restriction Fragment Length
MH  - Surveys and Questionnaires
MH  - Taiwan
EDAT- 2013/04/24 06:00
MHDA- 2013/11/08 06:00
CRDT- 2013/04/24 06:00
PHST- 2013/04/24 06:00 [entrez]
PHST- 2013/04/24 06:00 [pubmed]
PHST- 2013/11/08 06:00 [medline]
AID - 10.1097/JCP.0b013e3182900fb3 [doi]
PST - ppublish
SO  - J Clin Psychopharmacol. 2013 Jun;33(3):386-90. doi: 10.1097/JCP.0b013e3182900fb3.