PMID- 23609403
OWN - NLM
STAT- MEDLINE
DCOM- 20131107
LR  - 20221207
IS  - 1533-712X (Electronic)
IS  - 0271-0749 (Linking)
VI  - 33
IP  - 3
DP  - 2013 Jun
TI  - Association of brain serotonin transporter availability and brain-derived 
      neurotrophic factor in models of serotonin transporter genotypes in healthy 
      subjects.
PG  - 432-5
LID - 10.1097/JCP.0b013e3182904a80 [doi]
AB  - The S-allele of functional polymorphisms of the serotonin transporter (SERT) gene 
      has been demonstrated to have lower transcriptional activity compared with the 
      L-allele, which shows low expression of SERT in the brain. However, this finding 
      cannot be consistently replicated in vivo. The aim of this study was to determine 
      the availability of SERT based on SERT genotype. We also examined the 
      relationship between brain-derived neurotrophic factor (BDNF) and the 
      availability of SERT. Sixty-two healthy subjects were recruited. Each subject 
      underwent single-photon emission computed tomography with I-ADAM (I-labeled 
      2-([2-(dimethylaminomethyl)phenyl]thio)-5-iodophenylamine) for imaging SERT in 
      the brain. The specific uptake ratio was measured, and venous blood was drawn 
      when the subject underwent single-photon emission computed tomography to evaluate 
      BDNF levels and SERT genotype. All subjects expressed SERT genotypes that were 
      consistent with a biallelic model, and 26 subjects had SERT genotypes that were 
      consistent with a triallelic model. No differences in specific uptake ratio were 
      detected in the midbrain, putamen, caudate, and thalamus based on the SERT 
      genotype using the biallelic and triallelic models. Interestingly, The Pearson 
      correlation coefficient revealed a positive correlation between BDNF and SERT 
      availability. In particular, this relationship was observed in homozygous 
      S-allele expression and a genotype with low functional expression (SaSa/SaLg) in 
      the biallelic and triallelic models of SERT genotypes, respectively. This finding 
      might explain why the SS genotype of SERT did not increase the risk of major 
      depressive disorder in Asian populations and implicate an important role of BDNF 
      in the patients, who has the SS genotype of the SERT gene.
FAU - Chou, Yuan-Hwa
AU  - Chou YH
AD  - Department of Psychiatry, Taipei Veterans General Hospital & National Yang Ming 
      University, Taipei, Taiwan.
FAU - Chen, Chih-Ken
AU  - Chen CK
FAU - Wang, Shyh-Jen
AU  - Wang SJ
FAU - Tsai, Shih-Jen
AU  - Tsai SJ
FAU - Lirng, Jiing-Feng
AU  - Lirng JF
FAU - Liou, Ying-Jay
AU  - Liou YJ
FAU - Lin, Chun-Lung
AU  - Lin CL
FAU - Yang, Kai-Chun
AU  - Yang KC
FAU - Lin, Ming-Wei
AU  - Lin MW
FAU - Lo, Whai-Chin
AU  - Lo WC
FAU - Liao, Mei-Hsiu
AU  - Liao MH
FAU - Chen, Chia-Chieh
AU  - Chen CC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Psychopharmacol
JT  - Journal of clinical psychopharmacology
JID - 8109496
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Asian People/genetics
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Models, Genetic
MH  - Serotonin/metabolism
MH  - Serotonin Plasma Membrane Transport Proteins/*genetics
MH  - Tomography, Emission-Computed, Single-Photon
MH  - Young Adult
EDAT- 2013/04/24 06:00
MHDA- 2013/11/08 06:00
CRDT- 2013/04/24 06:00
PHST- 2013/04/24 06:00 [entrez]
PHST- 2013/04/24 06:00 [pubmed]
PHST- 2013/11/08 06:00 [medline]
AID - 10.1097/JCP.0b013e3182904a80 [doi]
PST - ppublish
SO  - J Clin Psychopharmacol. 2013 Jun;33(3):432-5. doi: 10.1097/JCP.0b013e3182904a80.