PMID- 23611358
OWN - NLM
STAT- MEDLINE
DCOM- 20131223
LR  - 20181202
IS  - 1365-2559 (Electronic)
IS  - 0309-0167 (Linking)
VI  - 62
IP  - 6
DP  - 2013 May
TI  - The prognostic impact of human leukocyte antigen (HLA) class I antigen 
      abnormalities in salivary gland cancer. A clinicopathological study of 288 cases.
PG  - 847-59
LID - 10.1111/his.12086 [doi]
AB  - AIMS: To study abnormalities of proteins of the major histocompatibility complex 
      class I in a series of 288 salivary gland carcinomas, and to correlate findings 
      with patients' overall survival (OS). METHODS AND RESULTS: Protein expression of 
      human leukocyte antigen (HLA)-A, heavy chain (HC)-10, beta2 -microglobulin, low 
      molecular weight polypeptides (LMP) 2 and 7, transporters associated with antigen 
      processing (TAP) 1 and 2, calnexin, calreticulin, endoplasmic reticulum (ER) p57 
      and tapasin was evaluated by immunohistochemistry and semiquantitatively 
      analyzed. As compared with normal salivary gland tissue, HLA-A, LMP7, TAP2 and 
      HLA class I were significantly down-regulated in salivary gland carcinomas, 
      whereas beta2 -microglobulin, calnexin, LMP2, and TAP1 were upregulated. Expression 
      of calreticulin, ERp57 and tapasin was unaltered. In univariate Kaplan-Meier 
      analyses, low expression of LMP7 (P = 0.005) and high expression of beta2 
      -microglobulin (P = 0.028), HLA-A (P < 0.001), TAP1 (P = 0.01), and tapasin (P < 
      0.001) were significantly associated with shorter OS. In multivariate analysis 
      incorporating tumour stage, nodal/distant metastasis, and grade, HLA-A (P = 
      0.014), LMP7 (P = 0.033), and tapasin (P = 0.024), as well as distant metastasis 
      (P = 0.012) and high tumour grade (P < 0.001), remained statistically 
      significant. CONCLUSION: The prognostic influence of up-regulated HLA-A and 
      tapasin and down-regulated LMP7 may provide a rationale for targeting these 
      specific components of the antigen processing and presentation pathway in 
      salivary gland carcinomas.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Muller, Maximilian
AU  - Muller M
AD  - Department of Pathology, University of Erlangen, Erlangen, Germany.
FAU - Agaimy, Abbas
AU  - Agaimy A
FAU - Zenk, Johannes
AU  - Zenk J
FAU - Ettl, Tobias
AU  - Ettl T
FAU - Iro, Heinrich
AU  - Iro H
FAU - Hartmann, Arndt
AU  - Hartmann A
FAU - Seliger, Barbara
AU  - Seliger B
FAU - Schwarz, Stephan
AU  - Schwarz S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Histopathology
JT  - Histopathology
JID - 7704136
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 2)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 3)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (HLA-A Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (TAP1 protein, human)
RN  - 0 (beta 2-Microglobulin)
RN  - 139873-08-8 (Calnexin)
RN  - 144416-78-4 (LMP-2 protein)
RN  - 145892-13-3 (TAP2 protein, human)
RN  - EC 3.4.22.- (Cysteine Endopeptidases)
RN  - EC 3.4.25.1 (LMP7 protein)
RN  - EC 3.4.25.1 (Proteasome Endopeptidase Complex)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 2
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 3
MH  - ATP-Binding Cassette Transporters/metabolism
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigen Presentation
MH  - Calnexin/metabolism
MH  - Child
MH  - Cysteine Endopeptidases/metabolism
MH  - Female
MH  - HLA-A Antigens/metabolism
MH  - Histocompatibility Antigens Class I/*metabolism
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Proteasome Endopeptidase Complex/metabolism
MH  - Salivary Gland Neoplasms/*immunology/*pathology
MH  - Tissue Array Analysis
MH  - Young Adult
MH  - beta 2-Microglobulin/metabolism
EDAT- 2013/04/25 06:00
MHDA- 2013/12/24 06:00
CRDT- 2013/04/25 06:00
PHST- 2012/07/15 00:00 [received]
PHST- 2012/12/14 00:00 [accepted]
PHST- 2013/04/25 06:00 [entrez]
PHST- 2013/04/25 06:00 [pubmed]
PHST- 2013/12/24 06:00 [medline]
AID - 10.1111/his.12086 [doi]
PST - ppublish
SO  - Histopathology. 2013 May;62(6):847-59. doi: 10.1111/his.12086.