PMID- 23611695
OWN - NLM
STAT- MEDLINE
DCOM- 20140113
LR  - 20211021
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 82
IP  - 1
DP  - 2013 Jul
TI  - The functional MICA-129 polymorphism is associated with skin but not joint 
      manifestations of psoriatic disease independently of HLA-B and HLA-C.
PG  - 43-7
LID - 10.1111/tan.12126 [doi]
AB  - A methionine/valine polymorphism at amino acid 129 of the major 
      histocompatibility complex class I chain-related gene A (MICA-129) categorizes 
      alleles into strong and weak binders of the natural killer (NK) and T-cell 
      receptor NKG2D. We investigated whether MICA-129 is differentially associated 
      with skin and joint manifestations of psoriatic disease (PsD) independently of 
      human leukocyte antigen (HLA)-C and HLA-B in patients and controls from Toronto 
      and St. John's. The MICA-129 methionine (Met) allele, particularly Met/Met 
      homozygosity, was strongly associated with both cutaneous psoriasis (PsC) and 
      psoriatic arthritis (PsA) independently of HLA-B and HLA-C in Toronto patients, 
      and was also associated with PsA in St. John's patients, but with no additional 
      effect of Met/Met homozygosity. No association remained after adjustment for HLA 
      alleles in St. John's patients. MICA-129 was not associated with PsA when 
      compared with PsC. We conclude that MICA-129 is a marker of skin manifestations 
      of PsD that is independent of HLA class I in Toronto patients.
CI  - (c) 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Pollock, R A
AU  - Pollock RA
AD  - University of Toronto Psoriatic Arthritis Program, Toronto Western Research 
      Institute, Toronto, Ontario, Canada.
FAU - Chandran, V
AU  - Chandran V
FAU - Pellett, F J
AU  - Pellett FJ
FAU - Thavaneswaran, A
AU  - Thavaneswaran A
FAU - Eder, L
AU  - Eder L
FAU - Barrett, J
AU  - Barrett J
FAU - Rahman, P
AU  - Rahman P
FAU - Farewell, V
AU  - Farewell V
FAU - Gladman, D D
AU  - Gladman DD
LA  - eng
GR  - RG/08/014/24067/BHF_/British Heart Foundation/United Kingdom
GR  - CAPMC/CIHR/Canada
GR  - MC_EX_G0902100/MRC_/Medical Research Council/United Kingdom
GR  - MR/L003120/1/MRC_/Medical Research Council/United Kingdom
GR  - U105261167/MRC_/Medical Research Council/United Kingdom
GR  - MC_U105261167/MRC_/Medical Research Council/United Kingdom
GR  - MR/L501566/1/MRC_/Medical Research Council/United Kingdom
GR  - G0902100/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130424
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (MHC class I-related chain A)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Demography
MH  - Female
MH  - Gene Frequency/genetics
MH  - *Genetic Predisposition to Disease
MH  - HLA-B Antigens
MH  - HLA-C Antigens/immunology
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Homozygote
MH  - Humans
MH  - Joints/*pathology
MH  - Logistic Models
MH  - Male
MH  - Multivariate Analysis
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Psoriasis/*genetics/*immunology
MH  - Skin/*pathology
EDAT- 2013/04/25 06:00
MHDA- 2014/01/15 06:00
CRDT- 2013/04/25 06:00
PHST- 2012/12/10 00:00 [received]
PHST- 2013/03/11 00:00 [revised]
PHST- 2013/03/29 00:00 [accepted]
PHST- 2013/04/25 06:00 [entrez]
PHST- 2013/04/25 06:00 [pubmed]
PHST- 2014/01/15 06:00 [medline]
AID - 10.1111/tan.12126 [doi]
PST - ppublish
SO  - Tissue Antigens. 2013 Jul;82(1):43-7. doi: 10.1111/tan.12126. Epub 2013 Apr 24.