PMID- 23612321 OWN - NLM STAT- MEDLINE DCOM- 20140424 LR - 20240323 IS - 1567-7257 (Electronic) IS - 1567-1348 (Print) IS - 1567-1348 (Linking) VI - 18 DP - 2013 Aug TI - The dynamics of GII.4 Norovirus in Ho Chi Minh City, Vietnam. PG - 335-43 LID - S1567-1348(13)00154-8 [pii] LID - 10.1016/j.meegid.2013.04.014 [doi] AB - Norovirus (NoV) is a major cause of epidemic gastroenteritis in industrialized countries, yet the epidemiological significance of NoV in industrializing countries remains poorly understood. The spatiotemporal distribution of NoV genotypes identified in 2054 enrolled children was investigated between May 2009 and December 2010, in Ho Chi Minh City (HCMC), Vietnam. A total of 315 NoV extracted from stool samples were genotyped and GPS mapped to their source. Genogroup II NoV, particularly GII.4, were predominant, and the GII.4 strains could be subgrouped into GII.4-2006b (Minerva) and GII.4-2010 (New Orleans) variants. There was no spatiotemporal structure among the endemic GII strains; yet a significant spatiotemporal signal corresponding with the novel introduction of GII.4-2010 variant was detected. These data show that NoV GII.4 variants are highly endemic in HCMC and describe a scenario of rapid NoV strain replacement occurring in HCMC in early 2010. CI - Copyright (c) 2013 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Tra My, Phan Vu AU - Tra My PV AD - Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, 764 Vo Van Kiet, District 5, Ho Chi Minh City, Viet Nam. FAU - Lam, Ha Minh AU - Lam HM FAU - Thompson, Corinne N AU - Thompson CN FAU - Phuc, Hoang Le AU - Phuc HL FAU - Tuyet, Pham Thi Ngoc AU - Tuyet PT FAU - Vinh, Ha AU - Vinh H FAU - Hoang, Nguyen Van Minh AU - Hoang NV FAU - Minh, Phamvan AU - Minh P FAU - Vinh, Nguyen Thanh AU - Vinh NT FAU - Thuy, Cao Thu AU - Thuy CT FAU - Nga, Tran Thi Thu AU - Nga TT FAU - Hau, Nguyen Thi Thu AU - Hau NT FAU - Chinh, Nguyen Tran AU - Chinh NT FAU - Thuong, Tang Chi AU - Thuong TC FAU - Tuan, Ha Manh AU - Tuan HM FAU - Campbell, James I AU - Campbell JI FAU - Clements, Archie C A AU - Clements AC FAU - Farrar, Jeremy AU - Farrar J FAU - Boni, Maciej F AU - Boni MF FAU - Baker, Stephen AU - Baker S LA - eng GR - WT_/Wellcome Trust/United Kingdom GR - 089276/WT_/Wellcome Trust/United Kingdom GR - 093724/WT_/Wellcome Trust/United Kingdom GR - 100087/WT_/Wellcome Trust/United Kingdom PT - Journal Article DEP - 20130421 PL - Netherlands TA - Infect Genet Evol JT - Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases JID - 101084138 SB - IM MH - Caliciviridae Infections/*virology MH - Child, Preschool MH - Cluster Analysis MH - Feces/virology MH - Gastroenteritis/*virology MH - Genotype MH - Geographic Information Systems MH - Humans MH - Infant MH - Infant, Newborn MH - Norovirus/*classification/genetics/isolation & purification MH - Phylogeography MH - Spatio-Temporal Analysis MH - Vietnam PMC - PMC4047827 OTO - NOTNLM OT - Cluster OT - GII.4 OT - Norovirus OT - Phylogenetic OT - Spatial OT - Temporal EDAT- 2013/04/25 06:00 MHDA- 2014/04/25 06:00 PMCR- 2013/08/01 CRDT- 2013/04/25 06:00 PHST- 2012/09/18 00:00 [received] PHST- 2013/04/05 00:00 [revised] PHST- 2013/04/06 00:00 [accepted] PHST- 2013/04/25 06:00 [entrez] PHST- 2013/04/25 06:00 [pubmed] PHST- 2014/04/25 06:00 [medline] PHST- 2013/08/01 00:00 [pmc-release] AID - S1567-1348(13)00154-8 [pii] AID - 10.1016/j.meegid.2013.04.014 [doi] PST - ppublish SO - Infect Genet Evol. 2013 Aug;18:335-43. doi: 10.1016/j.meegid.2013.04.014. Epub 2013 Apr 21.