PMID- 23612365
OWN - NLM
STAT- MEDLINE
DCOM- 20140207
LR  - 20171116
IS  - 1473-5830 (Electronic)
IS  - 0954-6928 (Linking)
VI  - 24
IP  - 5
DP  - 2013 Aug
TI  - Monocyte heterogeneity in myocardial infarction with and without ST elevation and 
      its association with angiographic findings.
PG  - 404-11
LID - 10.1097/MCA.0b013e328361a98c [doi]
AB  - OBJECTIVES: Monocytes and mature macrophages play significant roles after 
      myocardial infarction. Here, our aim is to investigate the monocyte heterogeneity 
      in acute ST elevation myocardial infarction (STEMI) and non-STEMI separately and 
      determine any possible relationships between monocyte heterogeneity and coronary 
      angiographic characteristics. METHODS: Thirty STEMI, 30 non-STEMI, and 25 stable 
      angina pectoris patients were enrolled. Blood samples were taken immediately at 
      admission, and on days 2, 3, 4, 5, and 7 after STEMI or non-STEMI for cytometric 
      analysis to determine monocyte heterogeneity. Peak creatine kinase (CK) and 
      CK-myocardial band (CK-MB) levels were used to determine the severity of 
      myocardial infarction. Coronary angiographic findings, such as the Gensini score, 
      the presence of acute total occlusion, and development of no reflow after 
      stenting, were noted. RESULTS: The peak levels of CD14++CD16- monocytes were 
      higher and were reached later in the STEMI group (631.6+/-116.7 vs. 539.6+/-103.0/mm, 
      P=0.003; day 2.73+/-0.64 vs. 2.27+/-0.74, P=0.011). Peak CK and CK-MB levels were 
      correlated positively with CD14++CD16- monocytes in the non-STEMI group. The 
      Gensini score was found to be correlated with the peak CD14+CD16+ monocyte levels 
      in the non-STEMI and stable angina pectoris groups. Patients with total occlusion 
      of the culprit artery had significantly higher levels of CD14++CD16- monocytes 
      (642.3+/-113.2 vs. 532.5+/-98.2/mm, P<0.001). The peak levels of CD14++CD16- 
      monocytes were higher in patients with no reflow compared with the patients with 
      thrombolysis in myocardial infarction grade 3 flow after percutaneous coronary 
      intervention of the culprit lesion (688.1+/-104.6 vs. 565.1+/-111.0, P=0.002). In 
      patients with no reflow, we also found higher peak CD14+CD16+ monocyte levels 
      (82.3+/-12.1 vs. 71.2+/-10.6, P=0.02). CONCLUSION: Monocyte heterogeneity differs in 
      STEMI and non-STEMI. Peak levels of CD14++CD16- monocytes were higher and were 
      reached later in the STEMI group compared with the non-STEMI group. More 
      importantly, worse angiographic characteristics related to prognosis are 
      associated with monocyte heterogeneity in both STEMI and non-STEMI patients.
FAU - Arslan, Ugur
AU  - Arslan U
AD  - Department of Cardiology, Samsun Education and Research Hospital, Samsun, Turkey. 
      ugurarslan5@yahoo.com
FAU - Kocaoglu, Ibrahim
AU  - Kocaoglu I
FAU - Balci, Mustafa M
AU  - Balci MM
FAU - Gulkan, Birsen
AU  - Gulkan B
FAU - Falay, Mesude Y
AU  - Falay MY
FAU - Temizhan, Ahmet
AU  - Temizhan A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Coron Artery Dis
JT  - Coronary artery disease
JID - 9011445
RN  - 0 (Biomarkers)
RN  - 0 (FCGR3B protein, human)
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 0 (Receptors, IgG)
RN  - EC 2.7.3.2 (Creatine Kinase, MB Form)
SB  - IM
MH  - Aged
MH  - Angina, Stable/blood/diagnostic imaging
MH  - Biomarkers/blood
MH  - Chi-Square Distribution
MH  - *Coronary Angiography
MH  - Creatine Kinase, MB Form/blood
MH  - Female
MH  - Flow Cytometry
MH  - GPI-Linked Proteins/blood
MH  - Humans
MH  - Lipopolysaccharide Receptors/blood
MH  - Male
MH  - Middle Aged
MH  - Monocytes/classification/*metabolism
MH  - Myocardial Infarction/*blood/*diagnostic imaging/therapy
MH  - No-Reflow Phenomenon/blood/etiology
MH  - Percutaneous Coronary Intervention/adverse effects
MH  - Phenotype
MH  - Predictive Value of Tests
MH  - Receptors, IgG/blood
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2013/04/25 06:00
MHDA- 2014/02/08 06:00
CRDT- 2013/04/25 06:00
PHST- 2013/04/25 06:00 [entrez]
PHST- 2013/04/25 06:00 [pubmed]
PHST- 2014/02/08 06:00 [medline]
AID - 10.1097/MCA.0b013e328361a98c [doi]
PST - ppublish
SO  - Coron Artery Dis. 2013 Aug;24(5):404-11. doi: 10.1097/MCA.0b013e328361a98c.