PMID- 23612669
OWN - NLM
STAT- MEDLINE
DCOM- 20140421
LR  - 20161018
IS  - 1437-4331 (Electronic)
IS  - 1434-6621 (Linking)
VI  - 51
IP  - 10
DP  - 2013 Oct
TI  - Relationship between coffee consumption, oxidant status, and antioxidant 
      potential in the Japanese general population.
PG  - 1951-9
LID - 10.1515/cclm-2013-0146 [doi]
AB  - BACKGROUND: Several previous studies have demonstrated an association between 
      habitual coffee intake and reduced risk of diabetes, cardiovascular morbidity and 
      total mortality. Although the cause and effect relationship could not be 
      determined through epidemiological data, antioxidant properties of coffee 
      ingredients are presumed. METHODS: In the current study, by analyzing the data 
      from 9877 subjects (mean age 59.2+/-10.4 years) who underwent general health 
      screening, we evaluated the extent of in vivo oxidative stress by measuring 
      derivatives of reactive oxygen metabolites (d-ROMs) and biological antioxidant 
      potential (BAP). RESULTS: The mean levels of d-ROM and BAP were significantly 
      lower in women than in men. By univariate analysis (ANOVA), coffee consumption 
      showed a graded negative association with d-ROM value in men, but not in women. 
      Coffee consumption was unrelated to BAP levels in men and women. Smoking was 
      significantly associated with increased d-ROM and decreased BAP values in men. 
      Multivariate-adjusted analysis showed that coffee intake of three or more cups 
      per day was an independent negative correlate of d-ROM value in men. Sugar use 
      was negatively associated with d-ROM and BAP values in women. CONCLUSIONS: Among 
      an essentially healthy population, coffee intake was negatively associated with 
      d-ROMs in men, but not in women. Whether the favorable effect of coffee, if 
      present, is related to lower oxidative stress levels needs further investigation.
FAU - Ishizaka, Yuko
AU  - Ishizaka Y
FAU - Yamakado, Minoru
AU  - Yamakado M
FAU - Toda, Akiko
AU  - Toda A
FAU - Tani, Mizuki
AU  - Tani M
FAU - Ishizaka, Nobukazu
AU  - Ishizaka N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
RN  - 0 (Antioxidants)
RN  - 0 (Coffee)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Antioxidants/*administration & dosage
MH  - Coffee/*chemistry
MH  - Female
MH  - Humans
MH  - Japan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress/*drug effects
MH  - Reactive Oxygen Species/antagonists & inhibitors/*blood
MH  - Risk Factors
MH  - Sex Factors
MH  - Smoking/epidemiology
EDAT- 2013/04/25 06:00
MHDA- 2014/04/22 06:00
CRDT- 2013/04/25 06:00
PHST- 2013/01/03 00:00 [received]
PHST- 2013/03/14 00:00 [accepted]
PHST- 2013/04/25 06:00 [entrez]
PHST- 2013/04/25 06:00 [pubmed]
PHST- 2014/04/22 06:00 [medline]
AID - /j/cclm.ahead-of-print/cclm-2013-0146/cclm-2013-0146.xml [pii]
AID - 10.1515/cclm-2013-0146 [doi]
PST - ppublish
SO  - Clin Chem Lab Med. 2013 Oct;51(10):1951-9. doi: 10.1515/cclm-2013-0146.