PMID- 23612867
OWN - NLM
STAT- MEDLINE
DCOM- 20140207
LR  - 20220311
IS  - 1573-0832 (Electronic)
IS  - 0301-486X (Linking)
VI  - 176
IP  - 1-2
DP  - 2013 Aug
TI  - Evaluation of Paracoccidioides brasiliensis infection by gp 43 intradermal test 
      in rural settlements in Central-West Brazil.
PG  - 41-7
LID - 10.1007/s11046-013-9656-x [doi]
AB  - Epidemiological studies of paracoccidioidomycosis have been based on surveys 
      achieved with intradermal tests, and paracoccidioidin is the most common antigen 
      used in most cases. The glycoprotein of 43-kDa (gp43) has been used in 
      intradermal tests. It is the most antigenic component of Paracoccidioides 
      brasiliensis, and it provides greater specificity to evaluate infection for this 
      fungus. In this study, the prevalence of P. brasiliensis infection was estimated 
      with intradermal tests involving gp43 for 695 people in rural Central-West 
      Brazil. The infection rate was 45.8 % (95 % CI = 42.1-49.5), and the average age 
      of those infected was 45.8 +/- 18.2 years. The prevalence did not show gender-based 
      differences but increased with age. The results demonstrate the importance of P. 
      brasiliensis infection in rural settlements and the early exposure of children in 
      the region to the fungus. Despite the high antigenicity and specificity of gp43, 
      its usage must be standardized, so that epidemiological surveys will be 
      comparable and more accurately reflect P. brasiliensis infection in endemic 
      areas.
FAU - Marques, Ana Paula da C
AU  - Marques AP
AD  - Universidade Federal do Mato Grosso do Sul, Cidade Universitaria s/n, Campo 
      Grande, 79070-900, Brazil.
FAU - Oliveira, Sandra Maria V L
AU  - Oliveira SM
FAU - Rezende, Grazielli R
AU  - Rezende GR
FAU - Melo, Dayane A
AU  - Melo DA
FAU - Fernandes-Fitts, Sonia M
AU  - Fernandes-Fitts SM
FAU - Pontes, Elenir Rose J C
AU  - Pontes ER
FAU - Bonecini-Almeida, Maria da Gloria
AU  - Bonecini-Almeida Mda G
FAU - Camargo, Zoilo P
AU  - Camargo ZP
FAU - Paniago, Anamaria M M
AU  - Paniago AM
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130424
PL  - Netherlands
TA  - Mycopathologia
JT  - Mycopathologia
JID - 7505689
RN  - 0 (43 kDa protein, Paracoccidioides)
RN  - 0 (Antigens, Fungal)
RN  - 0 (Fungal Proteins)
RN  - 0 (Glycoproteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Antigens, Fungal
MH  - Brazil/epidemiology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - *Fungal Proteins
MH  - *Glycoproteins
MH  - Humans
MH  - Infant
MH  - Intradermal Tests/*methods
MH  - Male
MH  - Middle Aged
MH  - Paracoccidioides/*immunology
MH  - Paracoccidioidomycosis/*diagnosis/*epidemiology
MH  - Prevalence
MH  - Rural Population
MH  - Sensitivity and Specificity
MH  - Young Adult
EDAT- 2013/04/25 06:00
MHDA- 2014/02/08 06:00
CRDT- 2013/04/25 06:00
PHST- 2012/09/23 00:00 [received]
PHST- 2013/04/11 00:00 [accepted]
PHST- 2013/04/25 06:00 [entrez]
PHST- 2013/04/25 06:00 [pubmed]
PHST- 2014/02/08 06:00 [medline]
AID - 10.1007/s11046-013-9656-x [doi]
PST - ppublish
SO  - Mycopathologia. 2013 Aug;176(1-2):41-7. doi: 10.1007/s11046-013-9656-x. Epub 2013 
      Apr 24.