PMID- 23615668
OWN - NLM
STAT- MEDLINE
DCOM- 20140107
LR  - 20221207
IS  - 1873-5126 (Electronic)
IS  - 1353-8020 (Linking)
VI  - 19
IP  - 7
DP  - 2013 Jul
TI  - Multicentre analysis of 178,992 type 2 diabetes patients revealed better 
      metabolic control despite higher rates of hypertension, stroke, dementia and 
      repeated inpatient care in patients with comorbid Parkinson's disease.
PG  - 687-92
LID - S1353-8020(13)00127-2 [pii]
LID - 10.1016/j.parkreldis.2013.03.011 [doi]
AB  - BACKGROUND: Especially in older people, physicians are faced with the coexistence 
      of type 2 diabetes mellitus (T2DM) and Parkinson's disease (PD). Therefore, this 
      research aimed to compare diabetes endpoints between T2DM with and without PD. 
      METHODS: Based on the standardized, multicenter, prospective DPV database, 
      178,992 T2DM patients (>/=40 years) were analyzed. 1579 were diagnosed with PD 
      and/or received specific treatment. Hierarchical multivariable regression models 
      were used for group comparisons; adjusted estimates based on observed marginal 
      frequencies were calculated. RESULTS: PD patients were significantly older (77.9 
      vs. 70.0 years; p < 0.0001) and had a longer diabetes duration (10.3 vs. 8.4 
      years; p < 0.0001). In young PD patients (<50 years), percentage of females was 
      significantly higher compared to age-matched T2DM patients without PD or people 
      of the German population (66.7 vs. 38.1 vs. 49.0%; p < 0.0001, p < 0.02). After 
      demographic adjustment, T2DM patients with PD showed a significantly lower HbA1c 
      (58.0 vs. 60.3 mmol/mol; p < 0.0001), OAD/GLP-1 treatment (41.9 vs. 45.9%; p < 
      0.01) and frequency of dyslipidemia (62.0 vs. 64.5%; p < 0.05). In contrast, 
      rates of insulin therapy (57.8 vs. 54.8%; p < 0.05), hypertension (73.3 vs. 
      68.6%; p < 0.001), antihypertensive medication (60.4 vs. 56.1%; p < 0.01), stroke 
      (12.0 vs. 7.3%; p < 0.0001), dementia (9.2 vs. 2.6%; p < 0.0001) and repeated 
      inpatient care (15.7 vs. 12.0%; p < 0.0001) were significantly higher and 
      duration of hospital stay (6.2 vs. 4.7 days; p < 0.0001) was significantly longer 
      in T2DM with PD. CONCLUSION: Clear demographic and clinical differences were 
      observed between T2DM with and without PD. In PD patients, metabolic control is 
      better, potentially due to more intensive medical care.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Scheuing, Nicole
AU  - Scheuing N
AD  - University of Ulm, Institute of Epidemiology and Medical Biometry, ZIBMT, 
      Albert-Einstein-Allee 41, 89081 Ulm, Germany. nicole.scheuing@uni-ulm.de
FAU - Best, Frank
AU  - Best F
FAU - Dapp, Albrecht
AU  - Dapp A
FAU - Dreyhaupt, Ines
AU  - Dreyhaupt I
FAU - Filz, Hans-Peter
AU  - Filz HP
FAU - Krakow, Dietmar
AU  - Krakow D
FAU - Lang, Wolfgang
AU  - Lang W
FAU - Siegel, Erhard
AU  - Siegel E
FAU - Zeyfang, Andrej
AU  - Zeyfang A
FAU - Holl, Reinhard W
AU  - Holl RW
CN  - DPV initiative and the German BMBF Competence Network Diabetes mellitus
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20130421
PL  - England
TA  - Parkinsonism Relat Disord
JT  - Parkinsonism & related disorders
JID - 9513583
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Austria
MH  - Chi-Square Distribution
MH  - Comorbidity
MH  - Dementia/*complications
MH  - Diabetes Mellitus, Type 2/*complications/epidemiology
MH  - Female
MH  - Germany
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Hypertension/*complications
MH  - *Inpatients
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/*epidemiology
MH  - Prospective Studies
MH  - Statistics, Nonparametric
MH  - Stroke/*complications
EDAT- 2013/04/26 06:00
MHDA- 2014/01/08 06:00
CRDT- 2013/04/26 06:00
PHST- 2012/12/20 00:00 [received]
PHST- 2013/03/13 00:00 [revised]
PHST- 2013/03/19 00:00 [accepted]
PHST- 2013/04/26 06:00 [entrez]
PHST- 2013/04/26 06:00 [pubmed]
PHST- 2014/01/08 06:00 [medline]
AID - S1353-8020(13)00127-2 [pii]
AID - 10.1016/j.parkreldis.2013.03.011 [doi]
PST - ppublish
SO  - Parkinsonism Relat Disord. 2013 Jul;19(7):687-92. doi: 
      10.1016/j.parkreldis.2013.03.011. Epub 2013 Apr 21.