PMID- 23616433
OWN - NLM
STAT- MEDLINE
DCOM- 20141125
LR  - 20211021
IS  - 1097-0193 (Electronic)
IS  - 1065-9471 (Print)
IS  - 1065-9471 (Linking)
VI  - 35
IP  - 4
DP  - 2014 Apr
TI  - Association between white matter fiber structure and reward-related reactivity of 
      the ventral striatum.
PG  - 1469-76
LID - 10.1002/hbm.22284 [doi]
AB  - Individual responsiveness to rewards or rewarding stimuli may affect various 
      domains of normal as well as pathological behavior. The ventral striatum/nucleus 
      accumbens (NAcc) constitutes a key brain structure in the regulation of 
      reward-appetitive behavior. It remains unclear, however, to which extent 
      individual reward-related BOLD response in the NAcc is dependent on individual 
      characteristics of connecting white matter fiber tracts. Using tract-based 
      spatial statistics (TBSS) and statistical parametric mapping (SPM) this combined 
      DTI - fMRI study investigated this question by correlating NAcc BOLD signal upon 
      receipt of a monetary reward with different white matter characteristics (FA, 
      axial diffusivity, radial diffusivity). The results show that increased integrity 
      of white matter as assessed by FA in the cingulate and corpus callosum, the 
      inferior fronto-occipital fasciculus, the anterior thalamic radiation and the 
      anterior limb of the internal capsule was positively correlated with 
      reward-related activation in the NAcc. There were no negative correlations as 
      well as no significant results regarding axial and radial diffusivity. These 
      findings indicate that microstructural properties of fiber tracts connecting, 
      amongst others, the cortex with the striatum may influence intensity of 
      reward-related responsiveness of the ventral striatum by constraining or 
      increasing efficiency in information transfer within relevant circuitries 
      involved in processing of reward.
CI  - Copyright (c) 2013 Wiley Periodicals, Inc.
FAU - Koch, Kathrin
AU  - Koch K
AD  - Department of Neuroradiology, Klinikum rechts der Isar, Technische Universitat 
      Munchen, Ismaningerstrasse 22, 81675 Munich, Germany; Department of Psychiatry 
      and Psychotherapy, Jena University Hospital, Philosophenweg 3, 07743 Jena, 
      Germany.
FAU - Wagner, Gerd
AU  - Wagner G
FAU - Schachtzabel, Claudia
AU  - Schachtzabel C
FAU - Schultz, C Christoph
AU  - Schultz CC
FAU - Gullmar, Daniel
AU  - Gullmar D
FAU - Reichenbach, Jurgen R
AU  - Reichenbach JR
FAU - Sauer, Heinrich
AU  - Sauer H
FAU - Zimmer, Claus
AU  - Zimmer C
FAU - Schlosser, Ralf G M
AU  - Schlosser RG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130424
PL  - United States
TA  - Hum Brain Mapp
JT  - Human brain mapping
JID - 9419065
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Brain/*anatomy & histology/*physiology
MH  - Brain Mapping
MH  - Diffusion Tensor Imaging
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Nerve Fibers, Myelinated/physiology
MH  - Neural Pathways/pathology/physiopathology
MH  - Neuropsychological Tests
MH  - Oxygen/blood
MH  - Probability
MH  - *Reward
MH  - Ventral Striatum/anatomy & histology/*physiology
PMC - PMC6869599
OTO - NOTNLM
OT  - DTI
OT  - anterior thalamic radiation
OT  - internal capsule
OT  - nucleus accumbens
OT  - reward
EDAT- 2013/04/26 06:00
MHDA- 2014/12/15 06:00
PMCR- 2013/04/24
CRDT- 2013/04/26 06:00
PHST- 2012/07/24 00:00 [received]
PHST- 2012/12/19 00:00 [revised]
PHST- 2013/02/12 00:00 [accepted]
PHST- 2013/04/26 06:00 [entrez]
PHST- 2013/04/26 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
PHST- 2013/04/24 00:00 [pmc-release]
AID - HBM22284 [pii]
AID - 10.1002/hbm.22284 [doi]
PST - ppublish
SO  - Hum Brain Mapp. 2014 Apr;35(4):1469-76. doi: 10.1002/hbm.22284. Epub 2013 Apr 24.