PMID- 23616511
OWN - NLM
STAT- MEDLINE
DCOM- 20130722
LR  - 20230216
IS  - 1541-6100 (Electronic)
IS  - 0022-3166 (Linking)
VI  - 143
IP  - 6
DP  - 2013 Jun
TI  - Psychosocial stimulation benefits development in nonanemic children but not in 
      anemic, iron-deficient children.
PG  - 885-93
LID - 10.3945/jn.112.160473 [doi]
AB  - Young children with iron deficiency anemia (IDA) usually have poor development, 
      but there is limited information on their response to psychosocial intervention. 
      We aimed to compare the effects of psychosocial stimulation on the development of 
      children with IDA and children who were neither anemic nor iron deficient (NANI). 
      NANI (n = 209) and IDA (n = 225) children, aged 6-24 mo, from 30 Bangladeshi 
      villages were enrolled in the study. The villages were then randomized to 
      stimulation or control, and all children with IDA received 30 mg iron daily for 6 
      mo. Stimulation comprised 9 mo weekly play sessions at home. We assessed 
      children's development at baseline and after 9 mo by using the Psychomotor 
      Development Index (PDI) and the Mental Development Index (MDI) of the Bayley 
      Scales of Infant Development-II, and rated their behavior during the test. When 
      we controlled for socioeconomic background, the IDA and NANI groups did not 
      differ in their Bayley scores and behavior at baseline. After 9 mo, the IDA group 
      had improved in iron status compared with baseline but had lower PDI scores and 
      were less responsive to the examiner than the NANI group. Random-effects 
      multilevel regressions of the final Bayley scores of the IDA and NANI groups 
      showed that stimulation improved children's MDI [B +/- SE = 5.7 +/- 1.9 (95% CI: 2.0, 
      9.4), P = 0.003], and the interaction between iron status and stimulation showed 
      a suggestive trend (P = 0.10), indicating that children with IDA and NANI 
      responded differently to stimulation, with the NANI group improving more than the 
      IDA group. In addition to iron treatment, children with IDA may require more 
      intense or longer interventions than NANI children.
FAU - Tofail, Fahmida
AU  - Tofail F
AD  - International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, 
      Bangladesh. ftofail@icddrb.org
FAU - Hamadani, Jena D
AU  - Hamadani JD
FAU - Mehrin, Fardina
AU  - Mehrin F
FAU - Ridout, Deborah A
AU  - Ridout DA
FAU - Huda, Syed N
AU  - Huda SN
FAU - Grantham-McGregor, Sally M
AU  - Grantham-McGregor SM
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20130424
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Anemia, Iron-Deficiency/drug therapy/*physiopathology/*psychology
MH  - Bangladesh
MH  - Child Development/*physiology
MH  - Child, Preschool
MH  - Cognition/physiology
MH  - Emotions/physiology
MH  - Humans
MH  - Infant
MH  - Iron/administration & dosage
MH  - Play and Playthings/psychology
MH  - Psychomotor Performance/*physiology
MH  - Socialization
EDAT- 2013/04/26 06:00
MHDA- 2013/07/23 06:00
CRDT- 2013/04/26 06:00
PHST- 2013/04/26 06:00 [entrez]
PHST- 2013/04/26 06:00 [pubmed]
PHST- 2013/07/23 06:00 [medline]
AID - S0022-3166(22)01213-5 [pii]
AID - 10.3945/jn.112.160473 [doi]
PST - ppublish
SO  - J Nutr. 2013 Jun;143(6):885-93. doi: 10.3945/jn.112.160473. Epub 2013 Apr 24.