PMID- 23619489
OWN - NLM
STAT- MEDLINE
DCOM- 20150413
LR  - 20211021
IS  - 1998-3689 (Electronic)
IS  - 0301-4738 (Print)
IS  - 0301-4738 (Linking)
VI  - 62
IP  - 3
DP  - 2014 Mar
TI  - Intraocular soluble intracellular adhesion molecule-1 correlates with subretinal 
      fluid height of diabetic macular edema.
PG  - 295-8
LID - 10.4103/0301-4738.111184 [doi]
AB  - OBJECTIVE: To investigate the correlations between aqueous concentrations of 
      vascular endothelial growth factor (VEGF), monocyte chemoattractant protein-1 
      (MCP-1), soluble intracellular adhesion molecule-1 (sICAM-1) and diabetic macular 
      edema (DME). MATERIALS AND METHODS: VEGF, MCP-1 and sICAM-1 concentrations in 
      aqueous humor samples of 22 patients with DME and 23 patients with cataract of a 
      control group were measured with solid-phase chemiluminescence immunoassay. 
      RESULTS: Aqueous VEGF (89.2 +/- 58.5 pg/ml versus 48.5 +/- 27.8 pg/ml, P = 0.006), 
      MCP-1 (684.2 +/- 423.4 pg/ml versus 432.4 +/- 230.4 pg/ml, P = 0.019) and sICAM-1 
      (3213.8 +/- 2581.6 pg/ml versus 260.2 +/- 212.2 pg/ml, P < 0.001) all vary 
      significantly between DME group and control group. Maximum height of submacular 
      fluid measured by Optical coherence tomography (OCT) was significantly associated 
      with aqueous sICAM-1 (r = -0.45, P = 0.034). The maximum height of macular 
      thickness measured by OCT was not significantly associated with either VEGF (P = 
      0.300), MCP-1 (P = 0.320) or sICAM-1 (P = 0.285). CONCLUSIONS: Our results 
      suggest that sICAM-1 may majorly contribute to the formation of subretinal fluid 
      in DME patients and imply that MCP-1 and sICAM-1 may be the potential therapy 
      targets, besides VEGF.
FAU - Zhu, Dan
AU  - Zhu D
AD  - Department of Ophthalmology, the Affiliated Hospital of Inner Mongolia Medical 
      College, Hohhot, Inner Mongolia, China.
FAU - Zhu, He
AU  - Zhu H
FAU - Wang, Chunyan
AU  - Wang C
FAU - Yang, Dayong
AU  - Yang D
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Ophthalmol
JT  - Indian journal of ophthalmology
JID - 0405376
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Aged
MH  - Aqueous Humor/*metabolism
MH  - Biomarkers/metabolism
MH  - Chemokine CCL2/metabolism
MH  - Diabetic Retinopathy/*complications/diagnosis/metabolism
MH  - Female
MH  - Fluorescein Angiography
MH  - Follow-Up Studies
MH  - Fundus Oculi
MH  - Humans
MH  - Immunoassay
MH  - Intercellular Adhesion Molecule-1/*metabolism
MH  - Macular Edema/diagnosis/etiology/*metabolism
MH  - Male
MH  - Subretinal Fluid/*metabolism
MH  - Tomography, Optical Coherence
MH  - Vascular Endothelial Growth Factor A/metabolism
PMC - PMC4061666
COIS- Conflict of Interest: None declared.
EDAT- 2013/04/27 06:00
MHDA- 2015/04/14 06:00
PMCR- 2014/03/01
CRDT- 2013/04/27 06:00
PHST- 2013/04/27 06:00 [entrez]
PHST- 2013/04/27 06:00 [pubmed]
PHST- 2015/04/14 06:00 [medline]
PHST- 2014/03/01 00:00 [pmc-release]
AID - 111184 [pii]
AID - IJO-62-295 [pii]
AID - 10.4103/0301-4738.111184 [doi]
PST - ppublish
SO  - Indian J Ophthalmol. 2014 Mar;62(3):295-8. doi: 10.4103/0301-4738.111184.