PMID- 23620119
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20181202
IS  - 2049-632X (Electronic)
IS  - 2049-632X (Linking)
VI  - 67
IP  - 1
DP  - 2013 Feb
TI  - Dendritic cell function in the host response to Helicobacter pylori infection of 
      the gastric mucosa.
PG  - 46-53
LID - 10.1111/2049-632X.12014 [doi]
AB  - Dendritic cells (DCs) play an important role as antigen-presenting cells that 
      direct the nature of the adaptive immune response. Subtypes are differentiated by 
      lineage, tissue, marker expression and function. Their function in promoting 
      regulatory T cells in the gut to maintain immunologic homeostasis is well 
      documented, but their role in the Helicobacter pylori-infected stomach is less 
      clear. Some analyses of bone marrow-derived DCs stimulated with H. pylori have 
      demonstrated proinflammatory potential based on secretion of IL-12 or IL-23 or 
      activation of Th1 and Th17 cells. Other analyses indicate that H. 
      pylori-activated DCs are less responsive compared with other gastrointestinal 
      bacteria and activate DCs to promote Treg development. DC depletion in mice 
      supports a role for DCs in down-regulating H. pylori-induced gastritis. These 
      data indicate that gastric DCs recognize H. pylori much like DCs in the gut that 
      recognize commensal organisms and promote a regulatory T-cell response. This is 
      consistent with a growing body of literature documenting the prevalence and 
      function of Treg cells in the host response to H. pylori. Research is now focused 
      on characterizing how H. pylori induces such activity in DCs and identifying the 
      mechanisms by which H. pylori-activated DCs activate Treg cells.
CI  - (c) 2012 Federation of European Microbiological Societies. Published by Blackwell 
      Publishing Ltd. All rights reserved.
FAU - Shiu, Jessica
AU  - Shiu J
AD  - Department of Pediatrics, University of Maryland School of Medicine, Baltimore, 
      MD, USA.
FAU - Blanchard, Thomas G
AU  - Blanchard TG
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130122
PL  - United States
TA  - Pathog Dis
JT  - Pathogens and disease
JID - 101595366
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Cytokines/metabolism
MH  - Dendritic Cells/*immunology
MH  - Gastric Mucosa/*immunology/*microbiology
MH  - Helicobacter Infections/*immunology/*microbiology
MH  - Helicobacter pylori/*immunology
MH  - Humans
MH  - Immune Tolerance
MH  - T-Lymphocytes, Regulatory/*immunology
EDAT- 2013/04/27 06:00
MHDA- 2013/11/13 06:00
CRDT- 2013/04/27 06:00
PHST- 2012/10/10 00:00 [received]
PHST- 2012/11/22 00:00 [revised]
PHST- 2012/11/23 00:00 [accepted]
PHST- 2013/04/27 06:00 [entrez]
PHST- 2013/04/27 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 10.1111/2049-632X.12014 [doi]
PST - ppublish
SO  - Pathog Dis. 2013 Feb;67(1):46-53. doi: 10.1111/2049-632X.12014. Epub 2013 Jan 22.