PMID- 2362097
OWN - NLM
STAT- MEDLINE
DCOM- 19900806
LR  - 20190817
IS  - 0192-0790 (Print)
IS  - 0192-0790 (Linking)
VI  - 12
IP  - 3
DP  - 1990 Jun
TI  - Familial occurrence of collagenous colitis. A report of two families.
PG  - 279-85
AB  - Collagenous colitis is a rare condition characterized clinically by chronic 
      diarrhea and histologically by a thickened subepithelial collagenous band in 
      colonic biopsies in an endoscopically normal colon. Familial occurrence of 
      collagenous colitis has to our knowledge never been described. Here we report two 
      families in which two first-degree related members suffered from collagenous 
      colitis. In one family, two sisters were affected by chronic diarrhea and 
      autoimmune disorders such as thyroid disease, rheumatoid arthritis, and 
      pernicious anemia. Collagenous colitis was diagnosed in one of these sisters, 
      based on colonic biopsies. Colonic biopsies of the other sister showed 
      microscopic colitis. Review of colonic biopsies of this patient taken 11 years 
      earlier, however, showed definite histological features of collagenous colitis. 
      In the other family, in a father and son, both with diarrhea for several years 
      but not suffering from any other diseases, a diagnosis of collagenous colitis was 
      made on colonic biopsies. Human leukocyte antigen (HLA) typing showed that only 
      the HLA A2 antigen was present in all 4 patients.
FAU - van Tilburg, A J
AU  - van Tilburg AJ
AD  - Department of Gastroenterology, Free University Hospital, Amsterdam, The 
      Netherlands.
FAU - Lam, H G
AU  - Lam HG
FAU - Seldenrijk, C A
AU  - Seldenrijk CA
FAU - Stel, H V
AU  - Stel HV
FAU - Blok, P
AU  - Blok P
FAU - Dekker, W
AU  - Dekker W
FAU - Meuwissen, S G
AU  - Meuwissen SG
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Clin Gastroenterol
JT  - Journal of clinical gastroenterology
JID - 7910017
RN  - 0 (Aminosalicylic Acids)
RN  - 4Q81I59GXC (Mesalamine)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aminosalicylic Acids/therapeutic use
MH  - Biopsy
MH  - Colitis/complications/diagnosis/drug therapy/*genetics
MH  - *Collagen
MH  - Diarrhea/etiology
MH  - Female
MH  - Humans
MH  - Intestinal Mucosa/pathology/ultrastructure
MH  - Male
MH  - Mesalamine
MH  - Microscopy, Electron
MH  - Middle Aged
EDAT- 1990/06/01 00:00
MHDA- 1990/06/01 00:01
CRDT- 1990/06/01 00:00
PHST- 1990/06/01 00:00 [pubmed]
PHST- 1990/06/01 00:01 [medline]
PHST- 1990/06/01 00:00 [entrez]
AID - 10.1097/00004836-199006000-00009 [doi]
PST - ppublish
SO  - J Clin Gastroenterol. 1990 Jun;12(3):279-85. doi: 
      10.1097/00004836-199006000-00009.