PMID- 23620997
OWN - NLM
STAT- MEDLINE
DCOM- 20130613
LR  - 20190923
IS  - 1550-7033 (Print)
IS  - 1550-7033 (Linking)
VI  - 9
IP  - 3
DP  - 2013 Mar
TI  - Effect of nanoscale-ZnO on the mechanical property and biocompatibility of 
      electrospun poly(L-lactide) acid/nanoscale-ZnO mats.
PG  - 417-23
AB  - Poly(L-lactide) acid (PLLA) was mixed with different content of nanoscale-ZnO 
      (N-ZnO) and spun into nonwoven mats by electrospinning, the effects of the 
      blending ratio of N-ZnO on mats morphology and mechanical properties were 
      investigated. The prepared mats were characterized with infrared spectrometry 
      (IR), Brunauer-Emmett-Teller (BET) surface area, the morphology and tensile test 
      were investigated by scanning electron microscope (SEM) and electronic universal 
      testing machine, respectively. The quantity of N-ZnO contained in mats was 
      determinated by Na2 EDTA titration method, then the N-ZnO loading coefficient (%, 
      NL) could be figured out. Infrared spectrometry showed that the electrospun 
      PLLA/N-ZnO mats were prepared successfully. When the concentration of N-ZnO 
      contained in the mats increased from 0 to 2% (w/v), the curves of stress-strain 
      indicated that the elastic modulus of mats ranged among 5.16 to 15.59 MPa. In 
      addition, the electrospun PLLA/N-ZnO exhibited lower cell proliferation for 
      UE7T-13 cells than electrospun PLLA mats and control. The results presented that 
      the N-ZnO added in the mats enhanced the toughness of PLLA/ZnO mats to some 
      extent, though the biocompatibility of blends was not good.
FAU - Ji, Xuyuan
AU  - Ji X
AD  - State Key Laboratory of Bioelectronics, School of Biological Science and Medical 
      Engineering, Nanjing 210096, P.R. China.
FAU - Wang, Ting
AU  - Wang T
FAU - Guo, Lingling
AU  - Guo L
FAU - Xiao, Jiangqiang
AU  - Xiao J
FAU - Li, Zhiyong
AU  - Li Z
FAU - Zhang, Liming
AU  - Zhang L
FAU - Deng, Yan
AU  - Deng Y
FAU - He, Nongyue
AU  - He N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biomed Nanotechnol
JT  - Journal of biomedical nanotechnology
JID - 101230869
RN  - 0 (Biocompatible Materials)
RN  - 0 (Polyesters)
RN  - 459TN2L5F5 (poly(lactide))
RN  - SOI2LOH54Z (Zinc Oxide)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/*pharmacology
MH  - Bone Marrow Cells/cytology/drug effects
MH  - Cell Line
MH  - Cell Proliferation/drug effects
MH  - Elastic Modulus/drug effects
MH  - Humans
MH  - Materials Testing/*methods
MH  - *Mechanical Phenomena/drug effects
MH  - Nanoparticles/*chemistry/ultrastructure
MH  - Polyesters/chemistry/*pharmacology
MH  - Rabbits
MH  - Spectrophotometry, Infrared
MH  - Whole Blood Coagulation Time
MH  - Zinc Oxide/*chemistry
EDAT- 2013/04/30 06:00
MHDA- 2013/06/14 06:00
CRDT- 2013/04/30 06:00
PHST- 2013/04/30 06:00 [entrez]
PHST- 2013/04/30 06:00 [pubmed]
PHST- 2013/06/14 06:00 [medline]
AID - 10.1166/jbn.2013.1556 [doi]
PST - ppublish
SO  - J Biomed Nanotechnol. 2013 Mar;9(3):417-23. doi: 10.1166/jbn.2013.1556.